Preparing for bed bug treatment is tedious yet important. Very comprehensive preparation is necessary when infestations are heavy and the bugs are widely dispersed. More limited prep may be adequate for light infestations since at these levels the bed bugs typically are more confined to sleeping areas (beds, sofas, and recliners). Pest control firms have their own policies, however, regarding preparation requirements which may also depend on the manner of treatment. 
This pair of bed bug bite photos below show the immediate (left) and next day (right) reaction after feeding a colony of bedbugs from a container in the lab. (That's why they are contained in a small circular area).  The hive-like immediate symptoms are replace by dark red rash type reaction the following day with inflammation and less severe redness radiating out to a larger area.  
Very helpful article, plus everyone’s comments. I wish you all the best of luck with bedbug problems. We went to a cabin near Yosemite before Christmas and I saw bugs on the bed. Luckily we didn’t sleep there and left right away. However I’m afraid some came home with us. About 3 weeks after our trip, I got a rash on my neck, but it’s not very itchy. Haven’t seen any bugs at home, but am worried. Will try the tips in the article–any suggestions how to heat a bedroom to 120 degrees?
Diagnosing bed bug bites can be hard for medical professionals. We often hear of doctors assuming a variety of skin conditions before bed bugs – especially doctors who haven’t encountered patients with bed bug bites before. While there is no specific test to determine whether bites are from bed bugs there are tests that can show whether or not it’s an insect bite. This is useful for ruling out issues like eczema or allergic reactions, but not for determining that any specific insect bite is a bed bug. To be sure you’ll want to check for other signs of bed bug infestation, such as the bugs themselves, moltings, and the characteristic staining of their blood meal feces.
The first thing is you have to be able to recognize and distinguish a bed bug from any other insect. Everything starts to look like a bed bug if you start to worry about them. An adult bed bug is about the size and shape of an apple seed. If it has not fed recently it will be flattened and brown. If it has fed it will be round in circumference and reddish. Immature bed bugs have a similar appearance to adults, with the smallest being the size of the head of a pin. You can then learn to look for their fecal spots, which can be easier to detect than the bugs themselves. Check your hotel rooms when you travel. And think twice before bringing home used furniture. If you are purchasing used furniture, ask the furniture store how they deal with bed bugs. If they have no plan whatsoever, that's probably not a good sign. If you purchase used clothing, put it through a clothes dryer on a medium to high setting for a cycle as soon as you bring it home. And before you move into an apartment, ask the landlord whether there has been a bed bug infestation, or whether the building has ever been treated for bed bugs.
Its important to note that bed bugs can easily be transferred from other locations (such as hotels, friends, etc.) into your bedroom, something your definitely want to avoid! Its important to always check your skin, clothing and bags for any signs of bed bugs (and their bites) before entering your bedroom after sleeping away from the home. If you have been bitten a couple times, there is usually no urgent need for medical care. In fact, there are a number of effective home remedies that you can use to treat these insect bites. However, sometimes medical assistance is required. When is this the case and how can you identify when professional help is needed?
An OTC antiseptic medication can be used for skin irritation that may then develop into an infection. As a precaution, do not use creams on broken or infected skin. If you have already been scratching, do not use these products on any raw or weeping areas. If you see signs of a skin infection, such as redness, don't use these creams in that area, and call your doctor.
Spray all baseboards, loose plaster, behind bed frames and headboards, beneath beds and furniture, and bedsprings and bed frames. Do not apply to furniture surfaces or mattresses where people will be laying or sitting unless using a product labeled for that type of treatment. Infested bedding should not be treated, but should be removed, placed in sealed plastic bags, and taken for laundering and drying at high temperature.

I just discovered the cause of my skin reaction this morning. Been spending a lot of time at a friends place and started to get red spots that were intense and itch. It just got worse and worse. The dermatologist did a biopsy and found no bacteria or virus. Skin scrapping found no fungus. It was a matter of finding out what was causing my skin to become so swollen I couldn’t see some of the bite marks. It only affected my legs, feet, arms, upper back, chest, neck, and shoulders. No midsection bites.
Bites on dogs and cats will look much like bites on people, and the pet owner may actually suspect a mosquito or flea bit the pet. As with people, bed bugs do not stay on pets, but return to a protected harborage site after feeding. In addition to bites, the presence of the bug’s feces, cast skins and the animal’s irritation at night are also indicators of bed bugs biting pets. Therefore, one of the best things to do is inspect the pet’s bedding and frequently groom the animal while being vigilant for the telltale signs of bed bug presence.
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