Bed bugs hide in seams of mattresses, box springs, bed frames, headboards, dresser tables, inside cracks or crevices, behind wallpaper, or any other clutter or objects around a bed during the day. Bed bugs are transmitted from place to place as people travel. They can be in the seams and folds of luggage, overnight bags, folded clothes, bedding, furniture, or anywhere else they find a place to hide.
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Reports of bedbugs can be found in the popular press and on hotel and travel review sites, and they appear to be making a comeback. The good news is that they typically do not pose serious health risks, even though their bites may be uncomfortable. These slides show you how to recognize bedbugs, know where they're hiding, and learn what to do to prevent getting bitten.
Mechanical approaches, such as vacuuming up the insects and heat-treating or wrapping mattresses, are effective.[3][6] An hour at a temperature of 45 °C (113 °F) or over, or two hours at less than −17 °C (1 °F) kills them.[6] This may include a domestic clothes drier for fabric or a commercial steamer. Bed bugs and their eggs will die on contact when exposed to surface temperatures above 180 degrees and a steamer can reach well above 230 degrees.[31][15] A study found 100% mortality rates for bed bugs exposed to temperatures greater than 50 °C (122 °F) for more than 2 minutes. The study recommended maintaining temperatures of above 48 °C for more than 20 min to effectively kill all life stages of bed bugs, and because in practice treatment times of 6 to 8 hours are used to account for cracks and indoor clutter.[32] This method is expensive and has caused fires.[6][15] Starving them is not effective as they can survive without eating for 100 to 300 days, depending on temperature.[6] One expert recommends not trying to get rid of bed bugs exclusively on one's own.[29]

The life cycle stages of a bed bug are egg, nymph, and adult. The reason they are called bed bugs is that they readily infest mattresses, bed frames and box springs. Eggs are laid along the edges of or around buttons on the mattresses. Eggs can also be glued to rough surfaces. Bed bug females lay about 200 eggs, usually at the rate of three or four a day. Eggs are placed in cracks, crevices and other isolated and protected shelters. Females lay eggs after a blood meal. Eggs will hatch in one or two weeks into Nymphs. Newly hatched bugs (Nymphs) begin feeding immediately. At room temperature, and with an available food supply, the nymphal period will last 14 to 30 days. They shed their skin (Instar) five times before becoming adults. Bed bugs will mate soon after becoming mature, so the time from egg hatch to egg laying is 4 to 9 weeks, under favorable conditions. The average life span of the bed bug is 6-12 months and they feed every 10 days or so during this time. Bed bugs can survive many months without a blood meal and their reproduction is high.
Application entails treating all areas where the bugs are found or tend to hide or crawl. This takes considerable effort and follow-ups are usually needed. Companies typically treat seams, folds and crevices of bed components, chairs and sofas, but usually will not spray the entire sleeping surface or seating area. They also do not spray bed sheets, blankets or clothing, which instead should be hot washed or heated in a dryer. 
I have read a lot and saw a video where professionals can heat up your house with a machine to 140deg which will kill the bed bugs.They do make bed bug sprays (raid and others) and you can get mattress covers at wallmart. the ones for allergens will do. Don’t forget to seal up zippers. Read you can mix baking soda and water to a paste put it on for an hour or so. Wichazel, st johns wort and lemon juice, aloe and peppermint oil in tub may help relieve itch. Hope this helps.
Fumigation using a penetrating gas is another way to de-infest dwellings or furnishings, but the procedure is only offered by certain companies. True fumigation is not the same as setting off a total release fogger or ‘bug bomb.’ (It should be noted that bug bombs are considered ineffective in the treatment of bed bugs, and can be quite dangerous if misused.) The fumigation process is technically complex and requires vacating the building for a period of days. The building is then sealed and injected with a lethal gas, usually sulfuryl fluoride. Because the entire building must be vacated, structural fumigation is logistically more challenging with multi-unit buildings such as apartments, than for single family homes. Bed bug fumigations tend to be more common in southern and western states, where the procedure is also used to control certain types of wood-dwelling termites.  
I’ve encountered mosquito bites, flea bites and spider bites, but never had I encountered bed bug bites, that is until I travelled to San Francisco, CA. I made the trip at least four times a year; however, this time was different—opting to stay in a nearby hotel instead of with family or friends. I remember lying in bed. The room was hot and stuffy, causing me to toss and turn throughout the night. When morning came, I was exhausted but began my usual morning routine eager to get on the road. After a quick rinse, I dragged myself over to the mirror; that’s when I noticed them—little red bumps across my chest. Quickly, I scurried over to the bed—pulling off sheets, flipping pillows, inspecting the mattress and the box spring—nothing! Ugh, how could this have happened? It was a top-rated hotel. Were these bed bug bites, or was it another blood-sucking insect?
These nocturnal creatures can hide in beds, floors, furniture, wood, and paper trash during the day. We humans usually become their dinner during the night, with peak biting activity just before dawn.They can obtain their meal in as little as three minutes, after which they are engorged and drop off the host, then crawl into a hiding place to digest their meal. Bedbugs can live for 10 months, and can go weeks without feeding.
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