Zonalon and Prudoxin (doxepin) are topical creams that can be prescribed for relief from itching. The active ingredient in these products is a topical tricyclic antidepressant and seems to work against itching by reducing histamine. Histamines are chemicals your body produces in response to injury or when having an allergic reaction. A prescription-strength cortisone cream may also help. In some cases, a prescription antihistamine will be given. 
Once an infestation is confirmed, an integrated pest management strategy should be employed. Promoted by the Environmental Protection Agency (EPA) and the Centers for Disease Control and Prevention, an integrated pest management strategy is a multi-faceted, comprehensive strategy that relies on knowledge of bedbug biology and habits, and the most up-to-date pest control methods.3 An integrated pest management strategy minimizes economic, environmental, and health hazards, and is most effective for small bedbug populations.
To prevent bringing bed bugs to one's own home, travelers are advised to take precautions after visiting an infested site: generally, these include checking shoes on leaving the site, changing clothes in a garage before returning to their home, and putting the used clothes in a clothes dryer outside the house. When visiting a new lodging, it is advised to check the bed before taking suitcases into the sleeping area and putting the suitcase on a raised stand to make bedbugs less able to crawl in. "An extreme measure would be putting the suitcase in the tub." Clothes should be hung up or left in the suitcase, and never left on the floor. [29] The founder of a company dedicated to bedbug extermination said that 5% of hotel rooms he books into were infested. He advised people never to sit down on public transport; check office chairs, plane seats and hotel mattresses, and monitor and vacuum home beds once a month.[30]
These things are the real vampires!!!! Just got bit over my eye, which now is all swollen and hurting, and 3 bites on my upper arm, caught the 2 little bugs on the wall next to my bed. Make sure that your bed is away from the walls. I use tea tree oil it helps to calm the itching down, I have a bad reaction to them. Not sure where the keep coming from and always in twos. Ahhhhhh!!!!!!! Can’t sleep
The decline of bed bug populations in the 20th century is often credited to potent pesticides that had not previously been widely available.[44] Other contributing factors that are less frequently mentioned in news reports are increased public awareness and slum clearance programs that combined pesticide use with steam disinfection, relocation of slum dwellers to new housing, and in some cases also follow-up inspections for several months after relocated tenants moved into their new housing.[66]
Bedbug bites typically are stealthy and not felt by the host. This is because they inject a numbing substance into the skin along with an anticoagulant agent to prevent blood from clotting at the feeding site. Itchy, red bites on the skin may be the first sign you've been bitten. Bites are most common on the arms and shoulders, and the bites often occur in straight rows, as pictured here.
Often, bedbug bites are clustered along lines usually following arms and legs. Theories range from the idea that bedbugs are feeding along blood vessels to the idea that bedbugs remain with their bodies touching the bedding while they feed, and the bugs are left to feed only along lines where the skin is touching the bedding in just the right manner.
3. Centers for Disease Control and Prevention; National Center for Environmental Health; Environmental Protection Agency. Joint Statement on Bed Bug Control in the United States from the U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Environmental Protection Agency (EPA). Atlanta, Ga.: National Center for Environmental Health; 2010.
The only way to stop getting bedbug bites is to eradicate them, but it will be difficult and time-consuming. You can try to address the problem yourself, but It is best to enlist a professional pest control service that can use nonchemical and chemical measures. If you are renting, notify your landlord as other units should be inspected and the landlord may be required to assist in the eradication.
An OTC antiseptic medication can be used for skin irritation that may then develop into an infection. As a precaution, do not use creams on broken or infected skin. If you have already been scratching, do not use these products on any raw or weeping areas. If you see signs of a skin infection, such as redness, don't use these creams in that area, and call your doctor.
Bed bugs are obligatory bloodsucking. They have mouth parts that saw through the skin, and inject saliva with anticoagulants and painkillers. Sensitivity of humans varies from extreme allergic reaction to no reaction at all (about 20%). The bite usually produces a swelling with no red spot, but when many bugs feed on a small area, reddish spots may appear after the swelling subsides.[15] Bedbugs prefer exposed skin, preferably the face, neck, and arms of a sleeping person.
Bedbugs are small, flat, wingless insects with six legs that, like mosquitoes, feed on blood from animals or people. They range in color from almost white to brown, but they turn rusty red after feeding. The common bedbug doesn't grow much longer than 0.2 inches (0.5 centimeters) and can be seen by the naked eye to the astute observer.  Bedbugs get their name because they like to hide in bedding and mattresses.
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