Application entails treating all areas where the bugs are found or tend to hide or crawl. This takes considerable effort and follow-ups are usually needed. Companies typically treat seams, folds and crevices of bed components, chairs and sofas, but usually will not spray the entire sleeping surface or seating area. They also do not spray bed sheets, blankets or clothing, which instead should be hot washed or heated in a dryer. 
Bedbug bite reactions are self-limited and typically resolve within one to two weeks without intervention.15 There is no evidence that any treatment alters the natural history of bedbug dermatitis.8 If pruritus is present, nonprescription topical antipruritic preparations containing the active ingredient doxepin, or intermediate potency corticosteroids may be beneficial. Mupirocin (Bactroban) and/or systemic antibiotics should be considered in the treatment of superinfected bites.8
I know when you get infested with these, the bedding and mattresses all have to go. We are just barely scraping by as it is, and we have a bed for each kid no matter how often they come to see us – including ours, that’s SEVEN mattresses and bedding sets. Our landlord is not returning our calls, and although I know that he is responsible for not treating the problem which (per neighbor reports) the previous tenants had, too. But the lawyer wants $500 to even send a LETTER, let alone go to court. And I keep thinking that even if we go to court and win, the courts will make him treat the apartment…not replace the furniture that’s effected because of it. So…we sleep on floors, with newspapers?

One bed bug will usually take more than one bite. Once a bed bug inserts its mouthparts and finds a suitable blood vessel, it will begin feeding. However, finding the right blood vessel may take more than one injection into the skin. In addition, bed bugs are very sensitive to movement by the host they are feeding on. Therefore, if a sleeping person moves, a feeding bed bug will probably withdraw its mouthparts and begin its search for a blood meal on another part of the body. It’s important to remember that the number of bites a person receives is not indicative of the number of bed bugs that feed on that person.
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