Bedbugs lurk in cracks and crevices and they've been living on human blood for centuries. Though they aren't known to transmit disease or pose any serious medical risk, the stubborn parasites can leave itchy and unsightly bites. However, bedbugs don't always leave marks. The best way to tell if you have a bedbug infestation is to see the live, apple-seed-size critters for yourself. Unfortunately, once bedbugs take up residence in homes and businesses, they can be difficult to exterminate without professional help.

That's very possible. I have heard of couples reporting that only one partner is getting bitten. The truth is that both are getting bitten, but only one has a reaction to the bites. Thirty percent of people or more don't react to bed bug bites at all, and the elderly are less reactive than the rest of the population. Among those people who do react to the bites, most of them don't respond to early bites, but develop a sensitivity to subsequent ones. Those individuals who are not sensitive to bed bug bites may not know they have an infestation. Because bed bugs are nocturnally active, it's hard to see other signs of their presence—unless you're accustomed to waking up at 3 A.M. and taking a census. With a huge infestation, bed bugs start to move away from the bed, so you're more likely to see one in an exposed place during the day. In very severe infestations people can become anemic. That takes a lot of bugs though—maybe 100,000 feeding once a week or more.

Bed bugs have five immature nymph life stages and a final sexually mature adult stage.[13] They shed their skins through ecdysis at each stage, discarding their outer exoskeleton.[14] Newly hatched nymphs are translucent, lighter in color, and become browner as they moult and reach maturity. Bed bugs may be mistaken for other insects, such as booklice, small cockroaches, or carpet beetles; however, when warm and active, their movements are more ant-like, and like most other true bugs, they emit a characteristic disagreeable odor when crushed.
Bed bugs have flat oval bodies, six legs, are reddish-brown in color and are similar in size to a dog tick - many have described the adults as resembling a flat apple seed. Adult bed bugs are approximately 1/4 inch long, while nymphs (juveniles) may be as small 1/16 of an inch. With feeding, they enlarge or engorge with blood. The adults turn from a brownish to reddish color, while the translucent nymphs may become bright red during the feeding process. 
Firstly, its important to remember that, despite their daily diet of blood, bed bugs will not transfer blood based diseases (such as AIDS, etc.). However, in very rare cases, these bites have been known to cause Anaphylaxis, which is an adverse allergic reaction that covers the entire body in a rash. After being bitten by a bed bug, be alert for any of these potential complications:

Every morning, even after countless treatments of our bed and linens, I wake up with 20-30 new bites. I react extremely strongly to them, they can swell as big as a half dollar, and they itch sO badly I often end up ripping them open, leaving them prone to infection. I’m now a diagnoses anemic, which the doctor is sure is because of the number of bites…they are literally eating me alive…and killing me.
Visit your doctor. You can also see a doctor for diagnosis if you do not find signs of bedbugs in your bed and cannot identify the source of the bites or rash. However, there is a very good chance that your physician will not be able to firmly diagnose that you have been bitten by a bedbug because the symptoms look so similar to those that result from other insect bites and skin conditions. Nevertheless, you may feel comforted by going to see your doctor, who can confirm for you that bedbugs pose little physical threat to humans.
Help!! I have had a long and exhausting experience with these nasty bugs. My mother in law had stayed at my house for a few nights and a few weeks later after returning home she discovered she had a severe infestation of bed bugs.. so of course I took precautions at my home thinking she gave them to me. I threw my mattress away then taped off my entire bed with very sticky tape. No signs or bites at all . Then a few weeks later my son started to sleep in his bed again and sure enough he woke up with 3 bites in the shape of a triangle that were swollen and itchy. I searched his bed and found a casing shell and 3 blood stains under his box spring .I called a exterminator he came out and said we had a mild infestation and there was no signs in my bed but he found one live bug in my son’s bed. He treated the bedrooms and living room. Then my son and i were getting these little bumps on our body that looked nothing like the triangle bites and didn’t itch so the exterminator came again and treated but found no evidence of bed bugs and this cycle happened four times! So he has treated my apartment 4 times and found no signs of bed bugs and even had a dog come out to sniff around .. this was all over the course of about 5 months . The exterminator insists that we do not have bed bugs anymore but my son is still getting these bumps on him, some are reds dots and some are skin colored but no complaining of itching . I’m very overwhelmed and exhausted and havery no idea what to think. I think the tape on my bed prevented them from getting back into my bed after I threw my mattress out but again the exterminator said tape does not work. Are they hiding somewhere else like in the walls to where the exterminator think the problem is gone ?
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If all other options have been exhausted, you may need to seek a professional PMP (Pest Management Professional). There are pesticides that are approved for professionals to use during a infestation. These pesticides, however, are not always effective, and typically not as effective as steam cleaning, excessive heat, or excessive cold. The exterminator may opt to treat the area with carbon dioxide.
My husband for 5 yrs had been getting bites on one knee and on his stomach about every other month or so. They are maybe 3 or 4 on stomach area and maybe 6 or 7 on the knee – always same knee and same area on stomach. We wondered about bed bugs so we put DE out, corked all openings and cracks, and sprayed – we have never seen signs of the bed bugs, we put the mattress and box springs in the bed bug proof cover. If it were bed bugs would they not bite some where else and would you not get more of them after all this time? The only bug we have seen are the ones that look like lady bugs sometimes but I understand they do not bite!
People don't often consider bed bugs until they've left their mark. The appearance of flat, red welts in zigzag lines or small clusters is a key sign of bed bugs on humans. Bed bugs can also leave their bites in straight rows and, while they don't spread diseases to humans, their bites are quite irritating and scratching them can lead to bleeding and infection.
Bedbugs are small, flat, wingless insects with six legs that, like mosquitoes, feed on blood from animals or people. They range in color from almost white to brown, but they turn rusty red after feeding. The common bedbug doesn't grow much longer than 0.2 inches (0.5 centimeters) and can be seen by the naked eye to the astute observer.  Bedbugs get their name because they like to hide in bedding and mattresses.
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