As bed bugs grow they molt, shedding their skin five times before reaching maturity. A blood meal is needed between each successive molt. Adult females also must feed in order to lay eggs. Under favorable conditions (70-80°F), the bugs can mature fully in as little as a month, producing multiple generations per year. Cooler temperatures or limited access to blood prolong the development time.
Pay attention to when the bites occur. Consider, for example, if you notice the bites after waking up when previously you hadn't noticed them. However, this can also be difficult to determine because each person's reaction time can vary significantly. Symptoms that result from the bite can manifest at any point from a couple of hours to more than a week after the bite occurred.
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In most infestations, consultation with a professional exterminator is advised because elimination is more likely to be effective if multiple pest management methods are used. These include monitoring devices, canine detection, clutter removal, vacuuming, heat or cold treatment, sealing cracks and crevices, and judicious use of nonchemical and chemical pesticides. Monitoring devices include moat-like devices (e.g., Climbup Insect Interceptor) that trap bedbugs ascending and descending furniture legs, and emitting devices that use carbon dioxide, heat, and/or chemicals (e.g., Nightwatch monitor) that attract and trap bedbugs. Specially trained dogs are reported to detect bedbugs with 97 percent accuracy and are able to differentiate live bedbugs and viable eggs from debris remaining from previous infestations.41 Vacuuming is a highly effective method for removing bedbugs, but not eggs because these adhere to surfaces.42 High-efficiency particulate air filters eliminate bedbug allergens and debris.42 Nonchemical treatments include petroleum jelly (which can be applied to legs of furniture to prevent bedbugs from ascending), heating, and freezing (see Table 36 for effective killing temperatures).
The best way to confirm that the bites are from bed bugs is to find other evidence of a bed bug infestation. Common telltale signs can be found on or near your mattress: pull up your sheets and check the seams and folds for thin black fecal streaks or small red blood spots. You might also find bed bugs, living or dead, and their discarded shells in various hiding places, such as the joints of your bed frame.
Considering how time-consuming and costly it can be to eradicate bed bugs, it’s prudent to take precautions and avoid infestations in the first place. Householders should be vigilant when acquiring used furnishings, especially beds and couches. Discarded items should be avoided, and secondhand articles should be examined closely before being brought into the home. Look carefully in the folds and seams of furniture for signs of bed bugs (see the previous section entitled "Description and Habits" for more details). There is no reason to stop shopping in consignment stores, yard sales, etc., but it would be prudent to run clothing and fabric items through the washer or dryer before storing them in the home. The risk of acquiring bed bugs from items purchased in antique stores would generally be insignificant.
To prevent bringing bed bugs to one's own home, travelers are advised to take precautions after visiting an infested site: generally, these include checking shoes on leaving the site, changing clothes in a garage before returning to their home, and putting the used clothes in a clothes dryer outside the house. When visiting a new lodging, it is advised to check the bed before taking suitcases into the sleeping area and putting the suitcase on a raised stand to make bedbugs less able to crawl in. "An extreme measure would be putting the suitcase in the tub." Clothes should be hung up or left in the suitcase, and never left on the floor.  The founder of a company dedicated to bedbug extermination said that 5% of hotel rooms he books into were infested. He advised people never to sit down on public transport; check office chairs, plane seats and hotel mattresses, and monitor and vacuum home beds once a month.
Hello all I just want to put this out there that heat is the best way to kill these little pests. I work for a company that uses heat to do structural pasteurization, in other words we heat the entire house up to 140°+ (which is higher than the the thermal kill point for bedbugs) for an hour or more (though they can only withstand that heat for less than 15 min) This has been the ONLY way to kill them with a 100% success rate since they are becoming resistant to chemicals and DDT is illegal. Some things work for some infestations but not for all, there are a lot of good ideas on here :-)
Unlike those of other insects, bed bug bites may sometimes appear in tight lines of multiple, small, red marks where multiple bed bugs have fed along an exposed area. Bed bug bites can cause itchiness. Initially, a victim may detect a slight burning sensation. The burning area then develops red bumps, known as papules or wheals (rash). In extreme cases, bites may swell dramatically or turn into blister-like skin inflammations.