Preparing for bed bug treatment is tedious yet important. Very comprehensive preparation is necessary when infestations are heavy and the bugs are widely dispersed. More limited prep may be adequate for light infestations since at these levels the bed bugs typically are more confined to sleeping areas (beds, sofas, and recliners). Pest control firms have their own policies, however, regarding preparation requirements which may also depend on the manner of treatment. 
If you know that you have the bugs. Get sealing covers the kind that encloses completely, one for the mattress and one for the box spring. That will trap those critters inside and they will eventually die in there. Next you will need to decide of what combination of treatments you wish to use. Its a job that you will have to keep up with for some time. Do your research online first.
Bedbugs are small wingless insects with a flat body. Like all insects, they have six legs. Their color can range from whitish to brown, but after feeding (on blood from animals or people), they appear rusty red. Bedbugs grow to about 0.5 cm in length and can be seen by the naked eye. Their name comes from the fact that they often hide in bedding or mattresses.
Avoidance is the best means of preventing bedbug infestation.8 While traveling, sleeping quarters and bedding should be closely inspected for signs of bedbugs. Suitcases should be placed on metal racks away from walls and furniture. Frequent travelers might consider obtaining a portable heating unit for luggage and clothing (e.g., Packtite) as an additional precaution. Items at yard sales and secondhand stores should also be carefully examined before purchase.8  All potentially infested items should be sorted and sealed in plastic bags and removed only when ready to be disinfested (see Table 36 for instructions regarding effective care of infested items). Wearing long-sleeved nightclothes can minimize exposed skin, and although insect repellants have not been shown to be reliably effective, oil of lemon eucalyptus or diethyltoluamide (DEET) might help deter bites.44,45
Bed bugs are small, brownish, flattened insects that feed solely on the blood of animals. Although the common bed bug (Cimex lectularius) prefers feeding on humans, it will also bite other warm-blooded animals, including dogs, cats, birds and rodents. It has done so since ancient times; bed bugs are mentioned in medieval European texts and classical Greek writings back to the time of Aristotle.
Bedbug bites, like all insect bites, can become infected through excessive scratching, as underneath the fingernails lies a host of bacterial pathogens. If your bites become infected, they will appear red and swollen, feel tender and may drain pus. Typically there will not be a fever unless a substantial area of the skin is involved. If you experience any of these symptoms, you must seek medical attention as it points to a secondary infection. Your physician may prescribe antibiotic therapy or, if the infection is mild, an antiseptic medication that you can buy without a prescription.[12][13][14]

Bed bugs are challenging to eradicate. Since they can hide in so many places, inspections must be thorough and elimination is not always a certainty. Whenever resources allow, it’s prudent to enlist the services of a professional. Experienced pest controllers know where to look for bed bugs, and have an assortment of tools at their disposal. Nonetheless, owners and occupants can assist the professional in several important ways. Affording access to all living areas is crucial, and excess clutter will need to be removed. Belongings strewn about rooms offer many places for the bugs to hide, and impede inspection and treatment. Since bed bugs can disperse throughout a building, it often will be necessary to inspect adjoining rooms and apartments as well. 
The best way to confirm that the bites are from bed bugs is to find other evidence of a bed bug infestation. Common telltale signs can be found on or near your mattress: pull up your sheets and check the seams and folds for thin black fecal streaks or small red blood spots. You might also find bed bugs, living or dead, and their discarded shells in various hiding places, such as the joints of your bed frame.

My daughter stayed at a friends for 2 nights…. And brought home bedbugs!! She has bites from the top of her head to her feet. The itching must be horrific. Poor child. After 2 days of not being able to stop the itching, as a last resort (on a Sun at 11pm) I told her to use a bathroom spray cleaner that had bleach in it. She only put it on her legs, but the itching stopped there, just not on arms, stomach or in her head. Don’t recommend bleach but she was able to get a couple hours of sleep. I will try several things to try to help her that I have read from previous comments. Thanks everyone….

I have no idea what works…. all the benedryl, cortizone, calamine lotion, and any cream/ointment said that they help with insect bites DOES NOT work. Once you start scratching, it’s over, you are going to scratch until the cows come home. If I am able to the trick is not to scratch at all. The enzyme is only released when you scratch, unless you are highly allergic like the picture that is show above, and I thought I was allergic, guess not.
Scrub infested surfaces with a stiff brush to dislodge eggs. Vacuum the room extensively. Use a vacuum hose attachment to thoroughly vacuum cracks and crevices on furniture and along baseboards on the walls. Vacuum along baseboards, furniture, bed stands, rails, headboards, foot boards, bed seams, tufts, buttons, edges of the bedding, as well as the edges of the carpets (particularly along the tack strips). A good vacuum cleaning job may remove particles from cracks and crevices to encourage greater insecticide penetration. Bed bugs cling tightly to surfaces, so it is best to vacuum by scraping the end of the vacuum attachment over the infested areas to pull out the bed bugs. Caution: It is not good to use a bristle attachment, because you may transfer bed bugs to other areas since they cling to the brush. Dispose of vacuum cleaner bags after you are finished in an outdoor trashcan.
THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.
Did you or someone else in your home recently come home from a trip? Bugs can stow away in clothing and in the recesses of your luggage. A good preventative measure is to check lodging you are staying in immediately after arrival. As mentioned before, signs are evident, even during the daytime, include the blood-colored excrement they leave behind.

Blood spots found on one’s sheets, bites and the presence of bed bug feces and cast skins are some of the indications of a bed bug infestation. Bites are commonly found on the parts of the body that are more likely to be exposed to bed bugs during sleep – the hands, neck, face, shoulders, legs and arms. While not always the case, bed bug bites are often grouped together in a small area and at times may occur in a line or a zigzag pattern. Bites normally look like small, flat or raised areas that may become inflamed, itchy, red or blistered. Bed bug bite reactions don’t always appear immediately after you’re bitten and may take a few days to begin causing symptoms. However, not everyone reacts to bed bug bites in the same manner.

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