Bed bugs are very resilient. Nymphs and adults can persist months without feeding which is unusual for most insects. The ability to survive without a blood meal is longer at cooler temperatures ― potentially up to a year or longer at 55°F or less. In temperature-controlled buildings, a more typical duration is about 2 to 6 months. Consequently, it is usually impractical to leave buildings unoccupied in hopes of ‘starving out’ an infestation. When infested dwellings such as apartments are vacated, bed bugs often disperse to nearby units, or reduce their activity until the unit is reoccupied. 
I too feel hopeless about the bed bugs, I clean scrub and now have noticed them on the mattress, walls, picture frames and just the other day on my laptop!! I’ve tried so hard to get rid of these animals and haven’t been able too, my arms and hands feel like I have small pox these things can get really annoying the itching never stops I’ve tried aloe and calamine and it’s just getting worse. I’ve spent sleepless nights looking for them and I haven’t been able to get rid of them

Never treat any bedding, mattress, etc. with anything other than the treatments listed: borax, enzyme cleaner, Comet, sodium borate. Other pesticides and exterminating fluids can be harmful to humans. Even so, bedding and mattresses treated with chemicals such as borax or Comet should be left outside to dry naturally in the sun, then wrapped in plastic before next use, so as not to irritate the skin.

Insecticides might also have their work cut out for them: Entomologists have known that the common bedbug has built up resistance to some typical insecticides such as those containing certain pyrethroid chemicals like deltamethrin, according to Entomology Today. Deltamethrin apparently paralyzes an insect's nervous system, according to Cornell University.
Pulled back the sheet and sure enough there were bugs. I saw 2, but I believe there were more. I killed the two then he went to report it to the front desk and they did nothing about it. We checked out the next day and i did not have a reaction until 3 days later after we left for Orlando. Went to the pharmacy, got lanacane oinment and other meds for the itching. Its been 2weeks since the bite and I’m still itching like crazy. Luckily I came on this site and i tried the baking soda paste and it seems to be working. I also used the witch hazel and will try raw aloe also. I hate to little black bugs.
 Adult bed bugs are about 3/16” long and reddish-brown, with oval-shaped, flattened bodies. They are sometimes mistaken for ticks, cockroaches, carpet beetles or other household insects. The immature bed bugs (nymphs) resemble the adults, but are smaller and lighter in color. Bed bugs do not fly, and they don’t jump like fleas do ― but they can crawl rapidly over floors, walls, ceilings and other surfaces. Adult females lay their eggs in secluded places, depositing 1, 2 or more eggs per day, potentially hundreds during their lifetime. The eggs are tiny (about the size of a dust spec), whitish and hard to see without magnification, especially on light-colored surfaces. When first laid, the eggs are sticky, causing them to adhere to surfaces. At room temperatures, bed bug eggs hatch in about a week. Newly emerged nymphs are straw-colored and no bigger than a pinhead.
The size of bed bug bites varies with a number of different factors. Bed bugs inject an anti-coagulant along with their saliva when they pierce the skin to take a blood meal. This anti-coagulant is mostly responsible for how a person reacts to the bite and determines the size of the bug’s bite. Since people will have various sensitivities to the bed bug’s bite, the size of the bite will vary, as well. Another factor that influences the size of a bed bug reaction is the number of times a person is bitten. Bite reactions of people bitten many times are also variable, and their response may be either more or less intense as the number of bites increases.