The safest and most effective approach to getting rid of bed bugs is heat treatment, in which a trained professional heats the home's rooms one by one to a temperature of 50 degrees Celsius and sustains the heat for four hours. Heat does not penetrate well into wall voids, though, so desiccant dusts are often applied to those areas. No single technique can eliminate bed bugs—combinations of approaches are essential to getting the job done.

Bed bugs are obligatory bloodsucking. They have mouth parts that saw through the skin, and inject saliva with anticoagulants and painkillers. Sensitivity of humans varies from extreme allergic reaction to no reaction at all (about 20%). The bite usually produces a swelling with no red spot, but when many bugs feed on a small area, reddish spots may appear after the swelling subsides.[15] Bedbugs prefer exposed skin, preferably the face, neck, and arms of a sleeping person.

The size of bed bug bites varies with a number of different factors. Bed bugs inject an anti-coagulant along with their saliva when they pierce the skin to take a blood meal. This anti-coagulant is mostly responsible for how a person reacts to the bite and determines the size of the bug’s bite. Since people will have various sensitivities to the bed bug’s bite, the size of the bite will vary, as well. Another factor that influences the size of a bed bug reaction is the number of times a person is bitten. Bite reactions of people bitten many times are also variable, and their response may be either more or less intense as the number of bites increases.