Zonalon and Prudoxin (doxepin) are topical creams that can be prescribed for relief from itching. The active ingredient in these products is a topical tricyclic antidepressant and seems to work against itching by reducing histamine. Histamines are chemicals your body produces in response to injury or when having an allergic reaction. A prescription-strength cortisone cream may also help. In some cases, a prescription antihistamine will be given. 
Unlike cockroaches and flies that feed on filth, there is often no relationship between bed bugs and cleanliness. Since the bugs feed solely on blood, pristine dwellings can be as vulnerable to infestation as are places of squalor. That said, poverty and privation can lead to increased risk of bed bug problems, as can the inability to hire a professional exterminator.    
Bed bugs often hide in seams, folds and crevices of mattresses, box springs, bed frames and headboards. A thorough inspection requires dismantling the bed so that upper and lower seams and surfaces can be examined. Things to look for are the bugs themselves, shed skins of the nymphs (immature bed bugs), and the blackish fecal spots. The dark spots of dried bed bug excrement are often present along mattress seams or wherever the bugs have resided. Box springs afford many places for bed bugs to hide, especially along the upper seams and underneath, where the bottom edge of the box rests on the frame. If an underlying dust cover is present, it may have to be removed to gain access for inspection and possible treatment. Successful treatment of mattresses and box springs can be difficult, however, and infested ones may need to be discarded or encased in a protective cover. 

Bedbugs have resurged worldwide and these blood-sucking insects (both the Cimex lectularius and Cimex hemipterus) are a problem in many homes and hotels. Fortunately, bedbugs aren't known to spread contagious diseases. However, it is difficult to eradicate an infestation and you will want to take steps to prevent bringing bedbugs home. Learn how to identify and treat these pests.
Known to be international travelers and expert hitchhikers, bed bugs are everywhere. As you travel, you increase your chances of being bit. However, knowing how to identify the bites and what your treatment options are will help you decide your next course of action. Learn more about where to look for bed bugs and how to avoid them with these great blogs:

My husband returned from a Military Deployment…and brought bed bugs home with him. The day after we realized we had them, an exterminator that specializes in Bed Bugs came to our house and sprayed. They scheduled themselves to come back in 14 days to spray again (to kill the new bugs that hatch after the initial spray). We were old the spray would kill all the adults and babies…and the second spray would get the new hatchlings. 3 days after the initial spray, we started seeing adult bugs again!
1. Mattress Safe Encasements: Mattress Safe Products are bed encasements to place over your mattress or boxspring so you don't have to throw them away. They are bedbug certified. If using a labeled insecticide on the mattress or boxspring first, apply on mattress or box springs then zip it up. It has a patented hook to keep the bed bugs inside the encasement so they cannot escape. Keep the encasement in place for one year (due to bed bug life cycles).
These bloodsuckers love exposed areas of flesh such as closest to their nest such as the face, forehead, arms and known to attack babies.. Those repeatedly bitten over time are more likely to become sensitive. You may even find the person sleeping next to you does not show any signs of bed bug bites while you do. In fact, the person next to you may not have been bitten at all – a good sign that the infestation is closest to you.
Thank you all for the advice I’m seeing on here. Hydrocortisone was doing nothing for these bites. I have a high tolerance for pain but these bites really made me want to cry. I tried the Veeno Oatmeal bath, Witch Hazel and the Aloe Vera and this is when I began to get relief. These bites were very uncomfortable. I still itch a little but the swelling has gone down tremendously. I keep the Aloe Vera and witch hazel handy for the itching.
Bring in only what is needed, and avoid sitting or placing coats and other items on beds, floors and sofas where the bugs commonly reside. Essential items can be placed on a tabletop or other hard surface, preferably away from bedrooms and sleeping areas. Better to sit on a hard (non-upholstered) chair than on sofas and recliners. Also try to avoid leaning or brushing against beds and upholstered furniture. If such items are carried out of infested dwellings (e.g., by sanitation workers or firefighters), it’s best to wrap them in plastic or at least not hold them against your body during transport. Emergency Medical (EMS) personnel may need to take additional precautions, such as removing a patient’s bed bug-infested shoes or clothing, or installing plastic sheeting before transporting them in the emergency vehicle.    
In most cases, the only way to say for sure whether it was a bedbug that bit you is to search for evidence of bedbugs living in your home. "Once you start to notice the itchy bites, the second giveaway is the presence of small blood spots on your sheets or mattress, usually resembling patches of rust,” Durham says. Those spots are left behind after a bedbug has been smashed.
Bed bugs occur in all regions of the globe.[7] Rates of infestations are relatively common, following an increase since the 1990s.[3][4][6] The exact causes of this increase is unclear; with proposals including greater travel, more frequent exchange of second-hand furnishings, a greater focus on control of other pests, and increasing resistance to pesticides.[4] Bed bugs have been known human parasites for thousands of years.[2]
Application entails treating all areas where the bugs are found or tend to hide or crawl. This takes considerable effort and follow-ups are usually needed. Companies typically treat seams, folds and crevices of bed components, chairs and sofas, but usually will not spray the entire sleeping surface or seating area. They also do not spray bed sheets, blankets or clothing, which instead should be hot washed or heated in a dryer. 
DIY approaches come with risk. It's not uncommon for someone to use a pest-control bomb or fogger that is available over the counter. These don't work well against bed bugs, according to research from Ohio State University. They can also expose people to toxic chemicals. Neither are over-the-counter aerosol insecticides effective against bed bugs. Most of these products have either pyrethrin or a pyrethroid as a main ingredient and those compounds have the same mode of action as DDT, which bed bugs have become resistant to. If you spray the bug directly you might kill it, but that is not going to get rid of the infestation. The problem is finding all the bed bugs. Some just can't be reached with insecticide. It's difficult for nonprofessionals to do anything more than kill what they can see, but that's just the tip of the iceberg in terms of what's there.
Hi can you respond to me privately? I inspected my bed mattress and linens for any signs of bed beg fecal matter and any grown bed bugs or spots of feces. I have not found any traces blood-type residue or brownish type feces in the mattress. Is it normal to find an occasional bites from something other than bed bugs? Sometimes after shaving, I will have red pimples where I have shaved.

We recently moved to Chicago into an apartment building. AFTER signing the lease the landlord told us that he sprayed for bed bugs every 3 months…I guess I thought this was precautionary? It wasn’t. I am apparently allergic to these bites, my husband & son, thank god, are not affected. So far nothing helps me with the itch for more than a minute but I just found this sight so hopefully something will work. We have bug bombed and bug sprayed with no luck. Washing everything helps for maybe a day? Tonight we sprayed bleach ALL OVER our mattress and attacked it with a blow-drier. Also, I’ve slathered myself in baby oil per a post here.
Reports of bedbugs can be found in the popular press and on hotel and travel review sites, and they appear to be making a comeback. The good news is that they typically do not pose serious health risks, even though their bites may be uncomfortable. These slides show you how to recognize bedbugs, know where they're hiding, and learn what to do to prevent getting bitten.
Hi, I am from the United states and have recently travelled to Poland. Decided to stay in an AirBnb in Warsaw. Everything was okay until a couple of days into the stay when I noticed what seemed like a very small cluster of small bites in the crook of my neck. Stranger still, on the opposite side of my neck, in the same location, there was another very small cluster of small bites. Ofcourse, I panicked. Washed everything three times, etc. The next few days, it seemed a couple of more would appear in the same area. In the crook region of my neck. But, NOT on my legs, feet, stomach, hands. Keep in mind, I sleep with very little clothes and thought it was weird that this “skin reaction” was not any where else. I did start wearing a new product in my hair and exactly where my hair falls usually, is pretty much where these little “bumps” appeared. I did try to do little experiments to test out the theory that I may just be having a skin reaction to a hair product. One night, after donning almost little to nothing sleepwear, I rubbed lemon juice all over my neck. The next morning, I did feel slightly better but I believe maybe one or two very small bites after I washed it. Lately, I’ve been securely wrapping my neck and covering it when I go to sleep and have recently stopped using said new product in my hair. The bumps seem to be darkening and going away and as usual, found nowhere else on my body. Occassionally, after running the crook of my neck area, it feels like one or two very small bumps will appear. I dont know. Is this a new level of highly sophisticated bed bugs that I’m dealing with? Or is it just a skin reaction and my mind is playing invisible bug warfare on me? Please note. I do not have lice and these very small bumps I mentioned before are way further down from my scalp. Crook of neck area. Just a little higher than where my collar bone is. Please advise. Have you heard of anything like this?
First, there should be a thorough inspection of areas that may be infested to identify bedbugs. Once a room is identified as infested, don't remove anything from the room unless it is sealed in a plastic bag. Furniture and items that you want to discard rather than treat should be bagged and destroyed so other people don't use them. Call your trash collection agency to arrange for an immediate pickup. Reduce the clutter in the room and discard any cardboard boxes as they can harbor bedbugs. Vacuum the area and seal the vacuum bag in a plastic bag and discard it.

Hello! I am not sure if we have bed bugs or not. It seems like I am the only one getting bit. We co-sleep with our children and neither of them have signs of any kind of bites. I wake up with bite marks underneath my breasts and sometimes behind my knees. The bites itch for only a few minutes and disappear a few minutes after. We have looked through our mattress and have found no signs of anything. No blood smears nor any fecal matter. Could my bites be caused by something else.
Scratching can cause superinfection, leading to impetigo, cellulitis, or folliculitis.27–32 Reactions typically resolve within one to two weeks without treatment.32 Systemic reactions have been described, including asthma, generalized urticaria, angioedema, iron deficiency anemia, and, very rarely, anaphylaxis.33–36 Although bedbugs have been suspected to be vectors of more than 40 microorganisms, there is no evidence that they are involved in the transmission of disease.5
It is important to remember that they have a very flat body that allows it to hide almost anywhere. During the initial onset of the infestation, they are only visible around the tufts and seams of the mattress. As the infestation grows, these bugs spread out and inhabit larger and larger areas. Generally they prefer rough surfaces like wood or paper for their harborages.
Visit your doctor. You can also see a doctor for diagnosis if you do not find signs of bedbugs in your bed and cannot identify the source of the bites or rash. However, there is a very good chance that your physician will not be able to firmly diagnose that you have been bitten by a bedbug because the symptoms look so similar to those that result from other insect bites and skin conditions. Nevertheless, you may feel comforted by going to see your doctor, who can confirm for you that bedbugs pose little physical threat to humans.
So wear a face mask and just… bleach the crap out of your bed frame. Cover the mattress, repeatedly super heat your bedding and such, and bleach bleach bleach. MAKE SURE TO CHECK YOUR MATTRESS COVER. I did kill a few trying to hide in the zipper area. I picked out the crawlies with gloves and killed them, then repeatedly did a bleach scrub in case of any eggs. I do recommend the sticky traps a lot because if you keep your bed away from any walls or furniture, then the sticky traps will let you know if the bed bugs are coming from elsewhere.
We helped a girl who we ran into who was being beaten by her B/F. She and her daughter stayed one night, and we got them to a safe place. Now we have bed bugs. I threw away our bed. (Our guest had used one of our blankets.) Thank God my landlord is going to get an exterminator! It’s at least $300 for them to come in. And yes, the itch is unbearable.
Oh, I just killed one crawling up my arm as I’m typing right now and it was filled with MY blood!!!…I don’t know what to do or where to turn…I’m a senior citizen and I am on a limited income so I can’t spend alot of money on this….I am so discouraged and sleep deprived that before I started typing this I sobbed for at least an hour…I cam covered in bed bug bites and treatment is not working anymore. I live in an apartment complex for people 65 and older and someone came down the hall and knocked on my door and ask me if I was alright…I just said I was having a bad night which is an understatement!!!
Another solution you hear about is vacuuming. You can vacuum up a lot of insects, but eggs are harder to get, and vacuuming won't in and of itself kill bed bugs. Indeed, vacuuming can end up spreading bed bugs to other rooms—when emptying the canister, for example. Pest control operators who use vacuums take measures to prevent bed bugs from escaping when the vacuum is emptied.
I just discovered the cause of my skin reaction this morning. Been spending a lot of time at a friends place and started to get red spots that were intense and itch. It just got worse and worse. The dermatologist did a biopsy and found no bacteria or virus. Skin scrapping found no fungus. It was a matter of finding out what was causing my skin to become so swollen I couldn’t see some of the bite marks. It only affected my legs, feet, arms, upper back, chest, neck, and shoulders. No midsection bites.

People don't often consider bed bugs until they've left their mark. The appearance of flat, red welts in zigzag lines or small clusters is a key sign of bed bugs on humans. Bed bugs can also leave their bites in straight rows and, while they don't spread diseases to humans, their bites are quite irritating and scratching them can lead to bleeding and infection.

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