This question is answered by the condition of the mattress and the size of infestation. If there are holes or tears in the gauze fabric or fabric of the mattress, bed bugs and eggs may be inside, as well as outside. There are restrictions on how beds can be treated with insecticides. We carry both Mattress Safe Bed Bug Encasements and ActiveGuard Mattress Liners.
Symptoms may not appear until some days after the bites have occurred.[5] Reactions often become more brisk after multiple bites due to possible sensitization to the salivary proteins of the bed bug.[3] The skin reaction usually occurs in the area of the bite which is most commonly the arms, shoulders and legs as they are more frequently exposed at night.[5] Numerous bites may lead to an erythematous rash or urticaria.[5]

Often, bedbug bites are clustered along lines usually following arms and legs. Theories range from the idea that bedbugs are feeding along blood vessels to the idea that bedbugs remain with their bodies touching the bedding while they feed, and the bugs are left to feed only along lines where the skin is touching the bedding in just the right manner.

Hi can you respond to me privately? I inspected my bed mattress and linens for any signs of bed beg fecal matter and any grown bed bugs or spots of feces. I have not found any traces blood-type residue or brownish type feces in the mattress. Is it normal to find an occasional bites from something other than bed bugs? Sometimes after shaving, I will have red pimples where I have shaved.
All these bed bugs can be dealt with. it is best to use a non chemical treatment to make it safe for your environment . here is one i found, food grade Diatomaceous Earth found at garden centers, follow instructions, and move beds away from the walls, sprinkle in the carpet deeply, on to base boards , ( it works like borax powder for fleas and roaches) .
Reactions to bed bug bites differ from person to person from none to a full-blown allergic reaction. A mild reaction may reveal flat, red bumps at the bite sites. A more severe reaction may include an irritating itch (as in my case), or swelling. Resisting the itch is incredibly difficult, but giving in to it can cause severe irritation to the skin, increasing your risk for an infection. It’s the chemicals in the bed bug’s saliva that trigger such reactions, some lasting more than two weeks.
Pay attention to when the bites occur. Consider, for example, if you notice the bites after waking up when previously you hadn't noticed them. However, this can also be difficult to determine because each person's reaction time can vary significantly. Symptoms that result from the bite can manifest at any point from a couple of hours to more than a week after the bite occurred.
As bed bugs grow they molt, shedding their skin five times before reaching maturity. A blood meal is needed between each successive molt. Adult females also must feed in order to lay eggs. Under favorable conditions (70-80°F), the bugs can mature fully in as little as a month, producing multiple generations per year. Cooler temperatures or limited access to blood prolong the development time. 
Our apartment is clean, but apparently this has little to do with it. We were told to put our dry clothes in the clothes dryer for 30 minutes at a high heat and bag them tightly, spray rubbing alchoha l92% to repel them from the bed , couch covers and seat cushions, as well as to dry our bedding, curtains, towels etc., and to remove the light covers from the plugs. They were reasonable (about$400 divided into monthly payments.)They will come twice, a month apart beginning two days from now, We’ve been vacuuming daily, and tightly securing debris. We were told that rubbing alcohol, sprayed in cushions and the bottom of shoes will repel them (92%). I was told that the most common place to pick them up is hospital and doctor’s waiting rooms. I write, and have a lot of boxed papers. I’ve emptied my drawers. I’m also not sure of what to do about my hanging paintings. I have enough problems right now, and just want this to end.
Bed bugs have five immature nymph life stages and a final sexually mature adult stage.[13] They shed their skins through ecdysis at each stage, discarding their outer exoskeleton.[14] Newly hatched nymphs are translucent, lighter in color, and become browner as they moult and reach maturity. Bed bugs may be mistaken for other insects, such as booklice, small cockroaches, or carpet beetles; however, when warm and active, their movements are more ant-like, and like most other true bugs, they emit a characteristic disagreeable odor when crushed.
The creatures don't have wings and they can't fly or jump. But their narrow body shape and ability to live for months without food make them ready stowaways and squatters. Bedbugs can easily hide in the seams and folds of luggage, bags and clothes. They also take shelter behind wallpaper and inside bedding, box springs and furniture. The ones that feed on people can crawl more than 100 feet (30 meters) in a night, but typically creep to within 8 feet (2.4 m) of the spot its human hosts sleep, according to the CDC.
Bed bugs are a growing problem in schools and daycares. Typically they are introduced by students or staff living with an infestation at home. Pinpointing where the bugs exist can be challenging in such environments since there are no beds or sleeping areas for the insects to congregate. (Similar challenges occur when bed bugs are found in offices, libraries and retail stores.) Usually only small numbers of bed bugs are spotted, often on a student’s clothing, backpack, chair or desk. While this does not necessarily confirm that the child’s residence also has bed bugs, the parents should be notified that the home should be inspected, preferably by a professional. Teachers, nurses, and staff should be educated about the bugs and what they look like. Bed bugs should also be considered if a student frequently has reddened itchy welts --but keep in mind such reactions can be for reasons other than bed bugs. 

The size of bed bug bites varies with a number of different factors. Bed bugs inject an anti-coagulant along with their saliva when they pierce the skin to take a blood meal. This anti-coagulant is mostly responsible for how a person reacts to the bite and determines the size of the bug’s bite. Since people will have various sensitivities to the bed bug’s bite, the size of the bite will vary, as well. Another factor that influences the size of a bed bug reaction is the number of times a person is bitten. Bite reactions of people bitten many times are also variable, and their response may be either more or less intense as the number of bites increases.
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