No two people react to bites in the same way, although some reactions are similar. Because of the saliva that they leave behind, the first reaction is usually severe itching and irritation. This is often followed by a raised appearance on the contacted area. Some people, however, react by having welts and hives all over the body. Still others will have small, pinkish bumps that are concentrated in one area.
Bedbug bites, like all insect bites, can become infected through excessive scratching, as underneath the fingernails lies a host of bacterial pathogens. If your bites become infected, they will appear red and swollen, feel tender and may drain pus. Typically there will not be a fever unless a substantial area of the skin is involved. If you experience any of these symptoms, you must seek medical attention as it points to a secondary infection. Your physician may prescribe antibiotic therapy or, if the infection is mild, an antiseptic medication that you can buy without a prescription.[12][13][14]
If you are experiencing itching, burning, and other forms of pain, there are a couple of treatment methods you could try. The most common recommendation is a topical corticosteroid cream or an anesthetic, which are applied directly to the wound and rubbed in to provide relief from the itching. A possible alternative to corticosteroids is calamine cream, though the FDA isn’t convinced of its effectiveness.

Here’s one for ya…I drive over the road truck. On Friday 8/13 it was miserably hot so I stayed the night in a reputable motel. I now have bed bugs in my truck!!!! I’m getting a new mattress but am going to tell them to wrap it and tape it real well until I get home and bomb my truck. Being such a small space I figure using an insect smoke bomb will work. Well, at least it better!!! I have tons of bites all over my ankles, feet, several on my face, on one arm and on both thighs. Yup, the itching sucks…
I am now living in Kuwait far from my family, I was helpless and don’t know what to do, i was chatting w/ my mom and told her about my problem regarding the red spot comes out on my the under arm, i was crying for help coz i though i am sick.. my mother was so worried about me, until i decided search on internet related to my problem that doing facebook… i found this site then now i know it’s bed bug i think i took it from my friend room when i was slept there and I’m not dying as what i thought.. But my problem is i can’t wear backless dress, short pants because of the scar … anyone can help me how to remover this scar? it’s too disaster.
Hi Samantha! I highly recommend spending about 15min to investigate your bed (especially on the corners and don’t forget to look under the sheets, etc). If there are no signs of bed bugs, then I suggest that you don’t worry about it. Additionally, I have had itchy bites after a nights sleep and it turned out to be a once off occurrence, so just take action if it keeps happening. Hope that helps, sorry for the delayed response.
Cracks and crevices of bed frames should also be examined, especially if the frame is wood. (Bed bugs have an affinity for wood and fabric more so than metal or plastic.) Wooden support slats, if present, should be removed and examined since bed bugs often congregate where the ends rest on the frame. Screw holes, knots and other recesses are also common hiding places. Headboards secured to walls should be removed and inspected. In hotels, the area behind the headboard is often the first place that bed bugs become established. Bed bugs also frequently hide within items stored under beds. 
Bed bugs remain a problematic pest across the United States, beyond just bed bug bites. In fact, one out of five Americans has  had a bed bug infestation in their home or knows someone who has encountered bed bugs. Reflecting the increasing problem with bed bugs,  a survey of pest management professionals found that prior to 2000 only 25 percent had encountered bed bug infestations, but in 2013 an amazing 99.6 percent of U.S. based professional pest management companies encountered bed bug infestations. Bed bugs are found in places beyond homes and hotels, such as hospitals, schools, doctors' offices, public transportation, college dorms, day cares, offices and any other places where humans live or gather.
2. Active Guard Liners: Active Guard Mattress Liners may be placed on beds and are effective as both preventative and active bed bug treatments. They kill bed bugs and dust mites within 72 hours and will prevent bed bugs from infesting mattresses. ActiveGuard Liners act like a fitted sheet; it comes in single, full, queen, and king sizes that fit up to 17" in depth.

Unlike those of other insects, bed bug bites may sometimes appear in tight lines of multiple, small, red marks where multiple bed bugs have fed along an exposed area. Bed bug bites can cause itchiness. Initially, a victim may detect a slight burning sensation. The burning area then develops red bumps, known as papules or wheals (rash). In extreme cases, bites may swell dramatically or turn into blister-like skin inflammations.
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