Hey Ruth! If there are absolutely no signs of bed bugs (upon close inspection), its unlikely that they are the cause for the bite marks. I recommend taking another look for dark brown marks (dried blood) and other signs of their presence. Regardless, if you want to kill any bug on that mattress, just get a handheld steamer and blast it. The heat will kill everything and its completely natural. Hope that helps!

If all other options have been exhausted, you may need to seek a professional PMP (Pest Management Professional). There are pesticides that are approved for professionals to use during a infestation. These pesticides, however, are not always effective, and typically not as effective as steam cleaning, excessive heat, or excessive cold. The exterminator may opt to treat the area with carbon dioxide.

I am so glad I came to this site, as it at least I don’t feel alone in this battle I’m fighting! It is 2am and I am sitting in my new recliner that my sister gave me last spring!! I love my recliner, but it is ruined as of tonight when as a last resort I decided to sleep in it since I have been driven out of my bed from these unrelenting bloodsuckers!
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One trick to make this disposal easier involves using the cut-off end of a nylon stocking (or a knee-high nylon stocking) and a rubber band. Insert the stocking (toe first) into the end of the vacuum suction wand/tube, leaving the opening of the stocking protruding out of the end of the suction wand. Then fold the stocking opening back over the end of the wand and use the rubber band to secure it there. When the vacuum is turned on and the bed bugs are sucked into the tube, they will be trapped in the stocking. Afterwards, carefully remove the rubber band and retrieve the bug-filled stocking. Then secure the end of the stocking with the rubber band and dispose of it. 
Not sure how we got it since we never go anywhere. Been dealing with this for almost a year. I have terrible bites, scars, scabs and bumps all up and down both hands and arms. Have a bite on my cheek and some on my neck. Hubby has bumps that you can’t see, but you can feel them. I am going crazy itching. I don’t like leaving the house because of how I look. I use cover up and foundation on my hands to mask how bad my hands look. I wear a long-sleeved, summer weight sweater to hide the mess on my arms. Plus I can pull the sleeves down to help cover some of my hands.
One bed bug will usually take more than one bite. Once a bed bug inserts its mouthparts and finds a suitable blood vessel, it will begin feeding. However, finding the right blood vessel may take more than one injection into the skin. In addition, bed bugs are very sensitive to movement by the host they are feeding on. Therefore, if a sleeping person moves, a feeding bed bug will probably withdraw its mouthparts and begin its search for a blood meal on another part of the body. It’s important to remember that the number of bites a person receives is not indicative of the number of bed bugs that feed on that person.
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