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Symptoms may not appear until some days after the bites have occurred.[5] Reactions often become more brisk after multiple bites due to possible sensitization to the salivary proteins of the bed bug.[3] The skin reaction usually occurs in the area of the bite which is most commonly the arms, shoulders and legs as they are more frequently exposed at night.[5] Numerous bites may lead to an erythematous rash or urticaria.[5]


Bedbugs live in any articles of furniture, clothing, or bedding, so they or their eggs may be present in used furniture or clothing. They spread by crawling and may contaminate multiple rooms in a home or even multiple dwellings in apartment buildings. They may also hide in boxes, suitcases, or other items that are moved from residence to residence or from a hotel to home. Bedbugs can live on clothing from home infestations and may be spread by a person unknowingly wearing infested clothing.
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
Español: tratar las picaduras de chinches, Deutsch: Bettwanzenbisse behandeln, Português: Tratar Picadas de Percevejos, Italiano: Trattare le Punture delle Cimici da Letto, Français: traiter des piqures de punaises de lit, Русский: лечить укусы клопов, 中文: 应对床虱叮咬, Nederlands: Bedwantsbeten behandelen, Čeština: Jak léčit štípance od štěnic, Bahasa Indonesia: Mengobati Gigitan Kutu Ranjang, Tiếng Việt: Trị Vết cắn Bọ rệp, 日本語: トコジラミの刺し跡を治療する, العربية: معالجة لدغات البقّ المنزلي, 한국어: 빈대에 물린 상처를 치료하는 법, ไทย: รักษารอยตัวเรือดกัด
Hello there Trish from Reno we found bed bugs oh my gosh, I am am the only one who has been getting bit last yr on my feet this yr on my hands. My husband saturated our mattress with rubbing alcohol baseboards and I am washing everything tomorrow should we spray our entire you’re house too even our cloth furniture? What else should we do. Thanks you for this site. Sleepless in Reno…
Once an infestation is confirmed, an integrated pest management strategy should be employed. Promoted by the Environmental Protection Agency (EPA) and the Centers for Disease Control and Prevention, an integrated pest management strategy is a multi-faceted, comprehensive strategy that relies on knowledge of bedbug biology and habits, and the most up-to-date pest control methods.3 An integrated pest management strategy minimizes economic, environmental, and health hazards, and is most effective for small bedbug populations.
Thank you so much for all the information. I just found a bed bug in my room at 5:00 AM in the morning. I have been getting these red itchy rashes for more than 2weeks . It’s extremely annoying and in spite of looking every where , I couldn’t find anything. These Biggs are so difficult to find. Now after reading this I feel they are even more difficult to eradicate.
Found worldwide, bedbugs are most common in developing countries. Still, reports of bedbugs in luxury hotels are not uncommon. They are most commonly found in areas like hostels, hotels, shelters, and apartment complexes where there are many visitors coming and going. When they enter your home, it's often because they have hidden in luggage, furniture, clothing, or boxes that are being moved. They can also travel on pets' fur. Increases in international travel may be responsible for the rise in bedbug sightings.
Cutaneous reactions to bedbug bites can vary widely and are easily confused with other conditions (Table 1).15–19 A typical lesion is a 2- to 20-mm, pruritic, erythematous maculopapule with a central hemorrhagic crust or vesicle.5,8 Macules, papules, wheals (Figure 3), vesicles, bullae, and nodules have all been reported,20 as have asymptomatic lesions with a barely visible punctum as the only evidence of a bite.8 Bites vary in number and are preferentially distributed in unclothed areas (e.g., face, neck, extremities). Unlike many other arthropod and insect bites, bedbug bites are rarely located in the popliteal fossae or axillae.21 Lesions can be noticeable immediately when waking up or several days later, with the reaction often progressing from delayed to immediate with subsequent exposures22–26  (Table 2). The classic bedbug rash is referred to as “breakfast, lunch, and dinner” because it commonly presents as several bites in a row or cluster 20 (Figure 4).

Mix 8 ml (about 1/3 oz)(measurements on the bottle) or one 8 ml vial of Temprid FX with one gallon of water. Remember to use what you mix-within 24 hours. Adjust the spray pattern to a mist by turning the nozzle. A low fine mist is best for most spraying, but you may need to use a stream to get into some cracks and crevices. If you can't get into the cracks and crevices use one of the aerosols described below with it's crack and crevice tips to reach into these areas.


Individuals who experience repeated bites over time may have more pronounced symptoms. Some people may also develop scarring or a skin infection from intense scratching of the skin. Rarely, a more severe systemic allergic reaction to a bedbug bite may develop. Some individuals may develop insomnia and anxiety from serious or repeated bedbug infestations.
The size of bed bug bites varies with a number of different factors. Bed bugs inject an anti-coagulant along with their saliva when they pierce the skin to take a blood meal. This anti-coagulant is mostly responsible for how a person reacts to the bite and determines the size of the bug’s bite. Since people will have various sensitivities to the bed bug’s bite, the size of the bite will vary, as well. Another factor that influences the size of a bed bug reaction is the number of times a person is bitten. Bite reactions of people bitten many times are also variable, and their response may be either more or less intense as the number of bites increases.
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