Amazingly, these sneaky little bloodsuckers dine on you without waking you. You don't feel their stealthy bite because they inject a numbing agent into your body, along with an anticoagulant to keep your blood flowing as they suck. The first sign of bedbugs may be itchy, red bites on the skin, usually on the arms or shoulders. Bedbugs tend to leave straight rows of bites.
Summer means more time outdoors–and more opportunity for annoying critters to bite you. Most of the time, all you’ll get is a little red bump with itching and maybe a little swelling. These insect bite symptoms can be treated easily with anti-itch creams and over-the-counter antihistamines. Occasionally, bites can cause allergic reactions that lead to severe swelling and shortness of breath; if that happens to you this season, you need to be seen by a doctor.
Application entails treating all areas where the bugs are found or tend to hide or crawl. This takes considerable effort and follow-ups are usually needed. Companies typically treat seams, folds and crevices of bed components, chairs and sofas, but usually will not spray the entire sleeping surface or seating area. They also do not spray bed sheets, blankets or clothing, which instead should be hot washed or heated in a dryer. 
To prevent bringing bed bugs to one's own home, travelers are advised to take precautions after visiting an infested site: generally, these include checking shoes on leaving the site, changing clothes in a garage before returning to their home, and putting the used clothes in a clothes dryer outside the house. When visiting a new lodging, it is advised to check the bed before taking suitcases into the sleeping area and putting the suitcase on a raised stand to make bedbugs less able to crawl in. "An extreme measure would be putting the suitcase in the tub." Clothes should be hung up or left in the suitcase, and never left on the floor. [29] The founder of a company dedicated to bedbug extermination said that 5% of hotel rooms he books into were infested. He advised people never to sit down on public transport; check office chairs, plane seats and hotel mattresses, and monitor and vacuum home beds once a month.[30]
First, remove all affected areas such as bed linens, clothing, sheets and pillowcases and wash them in borax. For non-washable surfaces, as in drawers or cabinets, dust talcum powder on the affected area. Vacuum the area thoroughly and purchase an enzyme cleaner to clean all possible surfaces. If there are open spots or crevices in the wall, dust them with talcum powder and caulk them shut. This cleaning process should be repeated as often as possible to rid your home of the infestation.

Data Sources: A PubMed search was completed in Clinical Queries using the key terms bedbug, rash, bites, and infestation. The search included meta-analyses, randomized controlled trials, clinical trials, case reports, and reviews. We also searched the online databases of the Environmental Protection Agency, Centers for Disease Control and Prevention, and Jefferson Clinical Images. Lastly, we used Essential Evidence Plus. Search dates: February through June 2011.
Bed bug bites can look a lot like other insect bites. Some clues that can suggest the presence of bed bugs include finding red, itchy bites upon awakening - especially if the bites line up in a row on the skin. Bed bugs typically bite at night on exposed areas of skin, so the bites are most commonly found on the face, neck, hands and arms. Although some people develop a bite reaction immediately, others may take two to three days before a reaction becomes noticeable, and not all people have obvious bed bug bite symptoms. A bed bug bite can appear as a tiny puncture wound without a surrounding reaction, and can easily be missed. In fact, 30 percent of individuals living in bed bug-infested dwellings report a lack of bites or skin reactions. This appears to be more common amongst the elderly. On the other hand, other people have exuberant reactions, with large, red, raised and itchy welts. This is especially true if one becomes sensitized to bed bug bites, so that with repeated bites there is an increased risk of an exaggerated reaction to bed bug bites.
Bites on dogs and cats will look much like bites on people, and the pet owner may actually suspect a mosquito or flea bit the pet. As with people, bed bugs do not stay on pets, but return to a protected harborage site after feeding. In addition to bites, the presence of the bug’s feces, cast skins and the animal’s irritation at night are also indicators of bed bugs biting pets. Therefore, one of the best things to do is inspect the pet’s bedding and frequently groom the animal while being vigilant for the telltale signs of bed bug presence.
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