I too feel hopeless about the bed bugs, I clean scrub and now have noticed them on the mattress, walls, picture frames and just the other day on my laptop!! I’ve tried so hard to get rid of these animals and haven’t been able too, my arms and hands feel like I have small pox these things can get really annoying the itching never stops I’ve tried aloe and calamine and it’s just getting worse. I’ve spent sleepless nights looking for them and I haven’t been able to get rid of them
Bed bugs were first mentioned in Germany in the 11th century, in France in the 13th century, and in England in 1583,[50] though they remained rare in England until 1670. Some in the 18th century believed bed bugs had been brought to London with supplies of wood to rebuild the city after the Great Fire of London (1666). Giovanni Antonio Scopoli noted their presence in Carniola (roughly equivalent to present-day Slovenia) in the 18th century.[52][53]
If you arrive home and discover that you have brought some unwanted guests home with you, immediately notify the hotel of your discovery. Having a possible infestation in hotels and motels can be a public relations nightmare for the owners. Politely ask them to pay for any and all costs incurred to rid your clothing and home of a possible new infestation.

However, low-level infestations are also much more challenging to find and correctly identify. Other insects, such as carpet beetles, can be easily mistaken for bed bugs. If you misidentify a bed bug infestation, it gives the bugs more time to spread to other areas of the house or hitchhike a ride to someone else's house to start a new infestation. Learn about identifying bed bugs.

Cutaneous reactions to bedbug bites can vary widely and are easily confused with other conditions (Table 1).15–19 A typical lesion is a 2- to 20-mm, pruritic, erythematous maculopapule with a central hemorrhagic crust or vesicle.5,8 Macules, papules, wheals (Figure 3), vesicles, bullae, and nodules have all been reported,20 as have asymptomatic lesions with a barely visible punctum as the only evidence of a bite.8 Bites vary in number and are preferentially distributed in unclothed areas (e.g., face, neck, extremities). Unlike many other arthropod and insect bites, bedbug bites are rarely located in the popliteal fossae or axillae.21 Lesions can be noticeable immediately when waking up or several days later, with the reaction often progressing from delayed to immediate with subsequent exposures22–26  (Table 2). The classic bedbug rash is referred to as “breakfast, lunch, and dinner” because it commonly presents as several bites in a row or cluster 20 (Figure 4).
I have what I guess can be described as a mild case of bed bugs in one of my cars, weird I know but in the process of taking care of it. Anyway I get bites around my elbows and it gets really itchy and bothersome for almost a week. What I found works wonders for me is simply taking 1000 mg of motrin once a day. I had a huge welt that looked swollen and red and taking motrin calmed it down and made it stop itching for almost a full day at a time.
Unlike those of other insects, bed bug bites may sometimes appear in tight lines of multiple, small, red marks where multiple bed bugs have fed along an exposed area. Bed bug bites can cause itchiness. Initially, a victim may detect a slight burning sensation. The burning area then develops red bumps, known as papules or wheals (rash). In extreme cases, bites may swell dramatically or turn into blister-like skin inflammations.