Hello all I just want to put this out there that heat is the best way to kill these little pests. I work for a company that uses heat to do structural pasteurization, in other words we heat the entire house up to 140°+ (which is higher than the the thermal kill point for bedbugs) for an hour or more (though they can only withstand that heat for less than 15 min) This has been the ONLY way to kill them with a 100% success rate since they are becoming resistant to chemicals and DDT is illegal. Some things work for some infestations but not for all, there are a lot of good ideas on here :-)
Check the mattress throughly, paying close attention to seams and tufts along the edges. Flip the mattress over and inspect the bottom carefully as well. Pay particular attention to any rips in the fabric. View the fabric on the bottom of the box spring and shine a flash light to verify that bed bugs have not penetrated the interior of the box spring.
Each of the following pictures of bed bug bites shows typical skin reactions to the insect's saliva. Most people  are not hypersensitive to the bites and will show no reaction at all with the exception of two small dots where the bedbug punctured the skin. Other people can develop red papular eruptions (raised inflamed areas) or in severe cases, blisters.
It often seems that bed bugs arise from nowhere. The bugs are efficient hitchhikers and are usually transported into dwellings on luggage, clothing, beds, furniture, and other items. This is a particular risk for hotels and apartments, where turnover of occupants is constant. Bed bugs are small and agile, escaping detection after crawling into suitcases, backpacks and belongings. Acquiring secondhand beds, couches and furniture is another way that the bugs are transported into buildings. Bed bugs also can be carried in on one’s clothing, shoes or wheelchair. Once bed bugs are introduced, they can crawl from room to room or floor to floor. They can also be transported throughout buildings on people and their belongings. 
Blood spots found on one’s sheets, bites and the presence of bed bug feces and cast skins are some of the indications of a bed bug infestation. Bites are commonly found on the parts of the body that are more likely to be exposed to bed bugs during sleep – the hands, neck, face, shoulders, legs and arms. While not always the case, bed bug bites are often grouped together in a small area and at times may occur in a line or a zigzag pattern. Bites normally look like small, flat or raised areas that may become inflamed, itchy, red or blistered. Bed bug bite reactions don’t always appear immediately after you’re bitten and may take a few days to begin causing symptoms. However, not everyone reacts to bed bug bites in the same manner.
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