Zonalon and Prudoxin (doxepin) are topical creams that can be prescribed for relief from itching. The active ingredient in these products is a topical tricyclic antidepressant and seems to work against itching by reducing histamine. Histamines are chemicals your body produces in response to injury or when having an allergic reaction. A prescription-strength cortisone cream may also help. In some cases, a prescription antihistamine will be given. 

Bed bugs (Cimex lectularius) are small, flat, parasitic insects that only feed on the blood of humans and animals while they sleep. They are reddish-brown in color, about 1mm to 7mm in size, and can live for several months without a blood meal. Bed bugs are not known to spread diseases, but their presence can cause itching and loss of sleep. Excessive scratching can increase the chance of secondary skin infections. Bed bugs are found all over the world and the cleanliness does not determine the presence of bed bugs.

Unlike those of other insects, bed bug bites may sometimes appear in tight lines of multiple, small, red marks where multiple bed bugs have fed along an exposed area. Bed bug bites can cause itchiness. Initially, a victim may detect a slight burning sensation. The burning area then develops red bumps, known as papules or wheals (rash). In extreme cases, bites may swell dramatically or turn into blister-like skin inflammations.
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