Cracks and crevices of bed frames should also be examined, especially if the frame is wood. (Bed bugs have an affinity for wood and fabric more so than metal or plastic.) Wooden support slats, if present, should be removed and examined since bed bugs often congregate where the ends rest on the frame. Screw holes, knots and other recesses are also common hiding places. Headboards secured to walls should be removed and inspected. In hotels, the area behind the headboard is often the first place that bed bugs become established. Bed bugs also frequently hide within items stored under beds. 
Went on vacation with my husband, just 3 weeks ago. Stayed at a motel in Daytona. Had a double bed. Slept with my husband the first night, we did not go under the cover. The next night slept in the other bed, went under the cover and low and behold felt something biting me in the middle of the night, so I went on top of the cover for the rest of the night. Told my husband about it when we awoke.
As mentioned earlier, applying insect repellent at bedtime will probably not deter bed bugs from biting. When working in severely infested dwellings, there may be some benefit to spraying tops and bottoms of shoes with DEET-based repellents. Those working in bed bug-infested environments may also want to hot wash or run clothing, etc. through a dryer upon returning home or to the office.    
According to textile experts (Drycleaning & Laundry Institute, Laurel, MD), most garments designated as ‘dry-clean only’ (e.g., cotton, wool, silk, linen, rayon, nylon) will not be harmed provided they are dry before being placed in a clothes dryer at a moderate temperature setting. Dry cleaning procedures also kill bed bugs, but there is a risk of infesting the establishment when buggy items are tagged and sorted. 
I don’t think my infestation is very extreme RIGHT NOW. i know for a fact they aren’t in or on the mattresses so that only leaves the crevices along the sides of the carpet. i got on my hands and knees to look but i still didn’t see anything. I KNOW THEY’RE THERE, WE HAVE THE BITE MARKS TO PROVE IT!!!!!! the little blood suckers are excellent at hiding.
Specks of blood on bedding, mattresses, or upholstered furniture such as couches and headboards: Look carefully at your blankets, sheets, and mattress pads and then check the mattress and box spring. Are there specks of blood anywhere, especially near the seams? If so, there could be a bed bug infestation. You should also check for specks of blood on all upholstered furniture, including couches and headboards.
Just recently had my first experience w/ bedbug bites in Nicaragua. Hundred plus bites in one night and over a period of three days they became so inflamed, there were tiny blisters on each bite. These suckers snacked on me like I was an all you can eat buffet. I itched 4 days straight and finally went to a pharmacy there, which prescribed me acne creme. Worked, I guess, at least psychologically. But the bites kept festering more and more.
If you have bed bug bites, they may or may not look like the ones on the pictures. The bed bug bite pictures are meant as a guidance that should be used to eliminate other common insect bites. Please note that allergic reactions and a few other insect bites can look exactly like bed bug bites, so you shouldn’t make this your only step in identifying the bite. If you aren’t sure, contact your doctor and let him or her look at it. So what do bed bug bites look like? Have a look at the bed bug bite pictures below and see if they look similar to your own bites. If you have been bitten by bed bugs, then you should start bed bug bite treatment as soon as possible.
No two people react to bites in the same way, although some reactions are similar. Because of the saliva that they leave behind, the first reaction is usually severe itching and irritation. This is often followed by a raised appearance on the contacted area. Some people, however, react by having welts and hives all over the body. Still others will have small, pinkish bumps that are concentrated in one area.
Bed bugs typically feed at night when we are sleeping. Even though these pests commonly feed for 5 minutes, the bite itself is painless and usually goes undetected at the time. In fact, bed bugs inject an anticoagulant (a blood thinner) as they feed, which makes feeding easier for the bed bug and also less detectable to you. Although you may not see the bed bugs, or feel their bites, they know when you are around. Bed bugs are attracted to warmth and carbon dioxide. So, if you are alive, warm, and breathing - then you are broadcasting loudly and clearly to all nearby bed bugs that "dinner is served!"

Pay attention to when the bites occur. Consider, for example, if you notice the bites after waking up when previously you hadn't noticed them. However, this can also be difficult to determine because each person's reaction time can vary significantly. Symptoms that result from the bite can manifest at any point from a couple of hours to more than a week after the bite occurred.
Bedbugs reproduce by a gruesome strategy appropriately named "traumatic insemination," in which the male stabs the female's abdomen and injects sperm into the wound. During their life cycle, females can lay more than 200 eggs, which hatch and go through five immature "nymph" stages before reaching their adult form, molting after each phase. [Infographic: Bedbugs: The Life of a Mini-Monster]
Adult bedbugs are reddish brown in color, flat, oval-shaped, wingless and approximately 4-5 millimeters in length. Immature bedbugs (nymphs) may be translucent or light tan in color and therefore very difficult to see. Bedbugs are often more red in color after feeding. Bedbugs are attracted by warmth, and they generally feed during the night, often just before dawn. They tend to feed every five to 10 days, though they can survive without feeding for several months. Bedbugs pierce the skin and inject saliva that contains anesthetics and anticoagulants into the host, which often make their bites painless initially. After feeding on the host's blood for several minutes, bedbugs will crawl back to their hiding place. They will generally try to hide and remain within close range of their warm-blooded host. Affected individuals may feel and see the consequences of the bedbug bite afterward, though many individuals will not develop any physical signs of a bite. Bedbugs do not transmit or spread human disease.
Bites on dogs and cats will look much like bites on people, and the pet owner may actually suspect a mosquito or flea bit the pet. As with people, bed bugs do not stay on pets, but return to a protected harborage site after feeding. In addition to bites, the presence of the bug’s feces, cast skins and the animal’s irritation at night are also indicators of bed bugs biting pets. Therefore, one of the best things to do is inspect the pet’s bedding and frequently groom the animal while being vigilant for the telltale signs of bed bug presence.
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