Bedbug bites typically are stealthy and not felt by the host. This is because they inject a numbing substance into the skin along with an anticoagulant agent to prevent blood from clotting at the feeding site. Itchy, red bites on the skin may be the first sign you've been bitten. Bites are most common on the arms and shoulders, and the bites often occur in straight rows, as pictured here.
Individual responses to bites vary, ranging from no visible effect (in about 20–70%),[5][3] to small macular spots, to prominent wheals and bullae formations along with intense itching that may last several days.[5] The bites often occur in a line. A central spot of bleeding may also occur due to the release of anticoagulants in the bug's saliva.[4]
Every morning, even after countless treatments of our bed and linens, I wake up with 20-30 new bites. I react extremely strongly to them, they can swell as big as a half dollar, and they itch sO badly I often end up ripping them open, leaving them prone to infection. I’m now a diagnoses anemic, which the doctor is sure is because of the number of bites…they are literally eating me alive…and killing me.
I use witch hazel with aloe vera (from Thayers). Apply with Q-tip or cotton ball. WORKS VERY WELL for me, especially when applied soon after bite is detected. Found that if it stings a bit when applied, it is likely that bite was recent, and more likely to reduce the itch. If I apply soon after a bite, I feel a little sting from the astringent, and the itch if often eliminated (although not sure how large the bugs are that bit me).

Encasing mattresses is one of many good parts of a solution, but it doesn't get rid of the infestation. There are going to be other bugs away from the mattress, hiding nearby. What mattress covers are good at is entombing the sometimes large number of bed bugs that can live on a mattress. And because the covers tend to be uniform in color and don't have a lot of seams that the bugs can hide in, it's easier to see the insects.
It is important to remember that they have a very flat body that allows it to hide almost anywhere. During the initial onset of the infestation, they are only visible around the tufts and seams of the mattress. As the infestation grows, these bugs spread out and inhabit larger and larger areas. Generally they prefer rough surfaces like wood or paper for their harborages.
Doctors often misdiagnose those afflicted because it is nearly impossible to tell, if you are experiencing an allergic reaction, what bit you. Often healthcare providers and individuals that have been bitten by a member of the Hemiptera order mistake bites for those of a mosquito. The only way to discern, with complete surety, what your bites are from, is to get a sample of what has bitten you.
Bedbugs may enter your home undetected through luggage, clothing, used beds and couches, and other items. Their flattened bodies make it possible for them to fit into tiny spaces, about the width of a credit card. Bedbugs do not have nests like ants or bees, but tend to live in groups in hiding places. Their initial hiding places are typically in mattresses, box springs, bed frames, and headboards where they have easy access to people to bite in the night.
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