Most bites will have a small clear area in the center surrounded by redness that may or may not be raised. People tend to become more sensitive and have larger reactions after each episode. Reactions can include itch, swelling, rash and wheals (large round red area on the skin). Severe reactions can cause skin blisters and trouble breathing, although these reactions are very rare. 

Zonalon and Prudoxin (doxepin) are topical creams that can be prescribed for relief from itching. The active ingredient in these products is a topical tricyclic antidepressant and seems to work against itching by reducing histamine. Histamines are chemicals your body produces in response to injury or when having an allergic reaction. A prescription-strength cortisone cream may also help. In some cases, a prescription antihistamine will be given. 
Bed bugs are very resilient. Nymphs and adults can persist months without feeding which is unusual for most insects. The ability to survive without a blood meal is longer at cooler temperatures ― potentially up to a year or longer at 55°F or less. In temperature-controlled buildings, a more typical duration is about 2 to 6 months. Consequently, it is usually impractical to leave buildings unoccupied in hopes of ‘starving out’ an infestation. When infested dwellings such as apartments are vacated, bed bugs often disperse to nearby units, or reduce their activity until the unit is reoccupied. 
Bring in only what is needed, and avoid sitting or placing coats and other items on beds, floors and sofas where the bugs commonly reside. Essential items can be placed on a tabletop or other hard surface, preferably away from bedrooms and sleeping areas. Better to sit on a hard (non-upholstered) chair than on sofas and recliners. Also try to avoid leaning or brushing against beds and upholstered furniture. If such items are carried out of infested dwellings (e.g., by sanitation workers or firefighters), it’s best to wrap them in plastic or at least not hold them against your body during transport. Emergency Medical (EMS) personnel may need to take additional precautions, such as removing a patient’s bed bug-infested shoes or clothing, or installing plastic sheeting before transporting them in the emergency vehicle.    

Considering how time-consuming and costly it can be to eradicate bed bugs, it’s prudent to take precautions and avoid infestations in the first place. Householders should be vigilant when acquiring used furnishings, especially beds and couches. Discarded items should be avoided, and secondhand articles should be examined closely before being brought into the home. Look carefully in the folds and seams of furniture for signs of bed bugs (see the previous section entitled "Description and Habits" for more details). There is no reason to stop shopping in consignment stores, yard sales, etc., but it would be prudent to run clothing and fabric items through the washer or dryer before storing them in the home. The risk of acquiring bed bugs from items purchased in antique stores would generally be insignificant.      
Went on vacation with my husband, just 3 weeks ago. Stayed at a motel in Daytona. Had a double bed. Slept with my husband the first night, we did not go under the cover. The next night slept in the other bed, went under the cover and low and behold felt something biting me in the middle of the night, so I went on top of the cover for the rest of the night. Told my husband about it when we awoke.
Our place is pretty cluttered so I was freaking out. Luckily we have hardwood floors and not carpet. We tried different things. It gets really hot here, so I loaded up any nearby sheets, pillows, comforters, clothes, etc into trash bags and tied them off so nothing could get out. I put those in the car so the sun could beat heat into them all day. Never thought I’d be so thankful for Texas summers… Still got bites. We bought a mattress cover. Still got bites. We thought, okay, maybe they’re coming from the wall socket from a neighbors or something. We couldn’t close it so we kept the bed away from furniture and walls and put sticky traps on the legs. Caught NO bed bugs but STILL GOT BITES. I was losing my mind.

But the bites will look different from person to person, and some people won’t develop any reaction whatsoever. “The same bedbug could bite two different people and one could have no reaction at all and the other can have an extreme reaction with a swollen arm or itchy rash,” says Eric Braun, a board-certified entomologist and business manager for the national pest control company Rentokil Steritech, who is based in Redding, Pennsylvania. Some people end up developing a rash that looks like eczema. (5)
The size of bed bug bites varies with a number of different factors. Bed bugs inject an anti-coagulant along with their saliva when they pierce the skin to take a blood meal. This anti-coagulant is mostly responsible for how a person reacts to the bite and determines the size of the bug’s bite. Since people will have various sensitivities to the bed bug’s bite, the size of the bite will vary, as well. Another factor that influences the size of a bed bug reaction is the number of times a person is bitten. Bite reactions of people bitten many times are also variable, and their response may be either more or less intense as the number of bites increases.
×