Bedbug bites, like all insect bites, can become infected through excessive scratching, as underneath the fingernails lies a host of bacterial pathogens. If your bites become infected, they will appear red and swollen, feel tender and may drain pus. Typically there will not be a fever unless a substantial area of the skin is involved. If you experience any of these symptoms, you must seek medical attention as it points to a secondary infection. Your physician may prescribe antibiotic therapy or, if the infection is mild, an antiseptic medication that you can buy without a prescription.[12][13][14]

When staying in a hotel, I check the bed before I bring the suitcase into the sleeping part of the room so that if I have to ask the manager for another room, then I haven't exposed my suitcase to the bugs. When settling in, I put my suitcase up on the suitcase stand or the desktop so that any bugs are less likely to crawl into it. An extreme measure would be putting the suitcase in the tub. If it's a porcelain tub, bed bugs would have a hard time crawling up it. It's also unlikely that they would randomly crawl up a tub, because it's not near the bed. But if I don't see bed bugs in the room when I inspect it, I just put my suitcase on the stand because I know the probability is really low that a bug is going to crawl up the stand and into my suitcase. I keep my clothes in the suitcase or hang them in the closet—I don't leave them on the floor because wandering bed bugs might crawl into them.
The size of bed bug bites varies with a number of different factors. Bed bugs inject an anti-coagulant along with their saliva when they pierce the skin to take a blood meal. This anti-coagulant is mostly responsible for how a person reacts to the bite and determines the size of the bug’s bite. Since people will have various sensitivities to the bed bug’s bite, the size of the bite will vary, as well. Another factor that influences the size of a bed bug reaction is the number of times a person is bitten. Bite reactions of people bitten many times are also variable, and their response may be either more or less intense as the number of bites increases.
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