Cutaneous reactions to bedbug bites can vary widely and are easily confused with other conditions (Table 1).15–19 A typical lesion is a 2- to 20-mm, pruritic, erythematous maculopapule with a central hemorrhagic crust or vesicle.5,8 Macules, papules, wheals (Figure 3), vesicles, bullae, and nodules have all been reported,20 as have asymptomatic lesions with a barely visible punctum as the only evidence of a bite.8 Bites vary in number and are preferentially distributed in unclothed areas (e.g., face, neck, extremities). Unlike many other arthropod and insect bites, bedbug bites are rarely located in the popliteal fossae or axillae.21 Lesions can be noticeable immediately when waking up or several days later, with the reaction often progressing from delayed to immediate with subsequent exposures22–26  (Table 2). The classic bedbug rash is referred to as “breakfast, lunch, and dinner” because it commonly presents as several bites in a row or cluster 20 (Figure 4).
This pair of bed bug bite photos below show the immediate (left) and next day (right) reaction after feeding a colony of bedbugs from a container in the lab. (That's why they are contained in a small circular area).  The hive-like immediate symptoms are replace by dark red rash type reaction the following day with inflammation and less severe redness radiating out to a larger area.  
Im staying with these people in another town going to school I am mid fifties, I always bring home like these brown bag like “dinners” my room got infested with ants and I cleaned it up, ever since then i have developed these very sore 1/4 in bumps on back near my right armpit its also very major on the back of my upper arm, it dose not itch but is sore, What the heck is it! Should I be concerned,Will it go away!Should I get some benedryl?My friend said it will go away in five days or so,Any suggestions?
The diagnosis of a bedbug bite can sometimes be difficult, as bedbug bites may appear similar to the bites of other insects. A health care professional will ask detailed questions and perform a physical exam, focusing on the skin. Other organ systems will also be examined to assess for any signs of an allergic reaction or for signs of infection. No blood tests or imaging studies will be necessary. If someone is able to bring in a specimen of the insect that may have bitten them, this can be helpful in making the diagnosis.
As mentioned earlier, applying insect repellent at bedtime will probably not deter bed bugs from biting. When working in severely infested dwellings, there may be some benefit to spraying tops and bottoms of shoes with DEET-based repellents. Those working in bed bug-infested environments may also want to hot wash or run clothing, etc. through a dryer upon returning home or to the office.    

Bedbugs often invade new areas after being carried there by clothing, luggage, furniture or bedding. The creatures don't discriminate between dirty and clean homes, which means even luxury hotels can be susceptible to bedbugs. The most at-risk places tend to be crowded lodgings with high occupant turnover, such as dormitories, apartment complexes, hotels and homeless shelters.
My boyfriend is staying with a man who rents a room out in his house. The last tenants had bed bugs and the living room couch and everything is infested and theyve been gone for a month. The bugs were dormant until a week or two ago. The man has sprayed the house with something that is supposed to kill bed bugs yet my boyfriend is continuously being bitten. We counted around 100 bites. They are swollen and the itching is making him crazy. He is unable to sleep at night. We are trying to convince the man to just throw the couch out. Since he has no carpet we believe the couch is their main breeding ground and the sprays DID NOT WORK.
Some firms want beds stripped and furniture moved before they arrive, while other firms prefer to inspect first and perform these tasks themselves. Clutter and belongings on floors (especially beneath beds) must be removed since they impede treatment and afford additional places for bugs to hide. Bedding and garments normally will need to be laundered and/or hot dried (120°F minimum) since they cannot be treated with insecticides. An effective and efficient alternative to laundering is to simply place bedding, clothing, toys, shoes, backpacks, etc., in a clothes dryer set at medium-to-high heat for 10 to 20 minutes. This can be done in lieu of washing and will kill all bed bug life stages. 
Vigilant travelers may also want to elevate suitcases off the floor on a stand, tabletop or other hard surface rather than storing them on the floor or another bed. Hyper-vigilant travelers may further opt to keep belongings in sealed plastic pouches and their suitcase in a zippered tote — however each traveler must decide how cautious they wish to be. 
2. Active Guard Liners: Active Guard Mattress Liners may be placed on beds and are effective as both preventative and active bed bug treatments. They kill bed bugs and dust mites within 72 hours and will prevent bed bugs from infesting mattresses. ActiveGuard Liners act like a fitted sheet; it comes in single, full, queen, and king sizes that fit up to 17" in depth.
My husband returned from a Military Deployment…and brought bed bugs home with him. The day after we realized we had them, an exterminator that specializes in Bed Bugs came to our house and sprayed. They scheduled themselves to come back in 14 days to spray again (to kill the new bugs that hatch after the initial spray). We were old the spray would kill all the adults and babies…and the second spray would get the new hatchlings. 3 days after the initial spray, we started seeing adult bugs again!
These things are the real vampires!!!! Just got bit over my eye, which now is all swollen and hurting, and 3 bites on my upper arm, caught the 2 little bugs on the wall next to my bed. Make sure that your bed is away from the walls. I use tea tree oil it helps to calm the itching down, I have a bad reaction to them. Not sure where the keep coming from and always in twos. Ahhhhhh!!!!!!! Can’t sleep

Dismantling bed frames in infested areas typically exposes bed bug hiding sites. Having access to these areas during cleaning is important. Stand up the box spring and shine a flashlight through the gauze fabric and look for bed bugs. If the fabric is torn (possible hiding place), remove fabric to prepare for spraying. If the mattress and or box springs are infested, you may want to consider Encasements by Mattress Safe. Once covered with these encasements, bed bugs can not enter or exit. There is no need to treat the mattress or box spring when using these encasements. Keep them on for a year.
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
The biggest problem with these bites is that, depending on the persons skin and their tolerance to bacteria, their appearance is different on different types of people. I have noticed in the past that if I get bitten by a mosquito, I get a rather large red mark (even without scratching), whereas my husbands skin hardly shows any signs of the bite.

Unlike those of other insects, bed bug bites may sometimes appear in tight lines of multiple, small, red marks where multiple bed bugs have fed along an exposed area. Bed bug bites can cause itchiness. Initially, a victim may detect a slight burning sensation. The burning area then develops red bumps, known as papules or wheals (rash). In extreme cases, bites may swell dramatically or turn into blister-like skin inflammations.
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