There are thousands of types of spiders (technically arachnids and not insects) crawling around the U.S., but only two of them–the black widow and the brown recluse–can cause serious problems, and even those are rare. Most of the time you’ll see red bumps that hurt and itch if you’re bitten by a spider. Very few people get the severe pain and cramping of a widow bite or the decaying ulcers of a recluse bite (although if you do, get medical help right away).
A definitive diagnosis of health effects due to bed bugs requires a search for and finding of the insect in the sleeping environment as symptoms are not sufficiently specific.[5] Bed bugs classically form a line of bites colloquially referred to as "breakfast, lunch, and dinner" and rarely feed in the armpit or behind the knee which may help differentiate it from other biting insects.[4] If the number in a house is large a pungent sweet odor may be described.[4] There are specially trained dogs that can detect this smell.[2]
Heat treatment: Heat of 120 F for two hours will kill bedbugs. Wash items in hot water (120 F or above). This may not be enough, though, so it's recommended that you place items in a clothes dryer on hot heat for at least 30 minutes. In a hot climate, you can bag items in a black plastic bag and leave them in direct sunlight for 24 hours. For travel or home use, there are portable heating units that can be used for clothing and luggage. A garment steamer can also be used on some items, such as luggage.
Once an infestation is confirmed, an integrated pest management strategy should be employed. Promoted by the Environmental Protection Agency (EPA) and the Centers for Disease Control and Prevention, an integrated pest management strategy is a multi-faceted, comprehensive strategy that relies on knowledge of bedbug biology and habits, and the most up-to-date pest control methods.3 An integrated pest management strategy minimizes economic, environmental, and health hazards, and is most effective for small bedbug populations.

It’s been over a week since the first attack. I did not know where or when I got bit. Then a few days later in the night, I connected the dots. At 3 am I was up comparing bite pics on the internet and sure enough my fear was confirmed. I slept on the couch which is only 10 feet away in my studio with no problem. I did not see the actual bugs. I went and bought Steri-Fab spray–a gallon of it. I cleaned, vacuumed, sprayed the crap out of everything. I washed all my bedding in hot water. I threw out a throw rug. Sprayed baseboards again and around that side of the apartment.
Once an infestation is confirmed, an integrated pest management strategy should be employed. Promoted by the Environmental Protection Agency (EPA) and the Centers for Disease Control and Prevention, an integrated pest management strategy is a multi-faceted, comprehensive strategy that relies on knowledge of bedbug biology and habits, and the most up-to-date pest control methods.3 An integrated pest management strategy minimizes economic, environmental, and health hazards, and is most effective for small bedbug populations.
Insect and spider bites and how to deal with them Insect and spider bites can occur almost unnoticed, or they can be painful. Either way, home treatment is usually enough for most symptoms. However, some bites can spread serious disease, such as Lyme disease and malaria. Find out how to protect against bites and what to do if someone has a severe reaction to a bite. Read now
Often, bedbug bites are clustered along lines usually following arms and legs. Theories range from the idea that bedbugs are feeding along blood vessels to the idea that bedbugs remain with their bodies touching the bedding while they feed, and the bugs are left to feed only along lines where the skin is touching the bedding in just the right manner.
This pair of bed bug bite photos below show the immediate (left) and next day (right) reaction after feeding a colony of bedbugs from a container in the lab. (That's why they are contained in a small circular area).  The hive-like immediate symptoms are replace by dark red rash type reaction the following day with inflammation and less severe redness radiating out to a larger area.  

I use witch hazel with aloe vera (from Thayers). Apply with Q-tip or cotton ball. WORKS VERY WELL for me, especially when applied soon after bite is detected. Found that if it stings a bit when applied, it is likely that bite was recent, and more likely to reduce the itch. If I apply soon after a bite, I feel a little sting from the astringent, and the itch if often eliminated (although not sure how large the bugs are that bit me).
The size of bed bug bites varies with a number of different factors. Bed bugs inject an anti-coagulant along with their saliva when they pierce the skin to take a blood meal. This anti-coagulant is mostly responsible for how a person reacts to the bite and determines the size of the bug’s bite. Since people will have various sensitivities to the bed bug’s bite, the size of the bite will vary, as well. Another factor that influences the size of a bed bug reaction is the number of times a person is bitten. Bite reactions of people bitten many times are also variable, and their response may be either more or less intense as the number of bites increases.
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