Bed bugs can result in a number of health effects including skin rashes, psychological effects and allergic symptoms. Bed bug bites may lead to skin changes ranging from non visible to prominent blisters. Symptoms may take between minutes to days to appear. Itchiness is common, while some may feel tired or have a fever. Typically uncovered areas of the body are affected. Classically three bites occur in a row. Bed bugs bites are not known to transmit any infectious disease.
Bed bugs were mentioned in ancient Greece as early as 400 BC, and were later mentioned by Aristotle. Pliny's Natural History, first published circa AD 77 in Rome, claimed bed bugs had medicinal value in treating ailments such as snake bites and ear infections. (Belief in the medicinal use of bed bugs persisted until at least the 18th century, when Guettard recommended their use in the treatment of hysteria.)
That's very possible. I have heard of couples reporting that only one partner is getting bitten. The truth is that both are getting bitten, but only one has a reaction to the bites. Thirty percent of people or more don't react to bed bug bites at all, and the elderly are less reactive than the rest of the population. Among those people who do react to the bites, most of them don't respond to early bites, but develop a sensitivity to subsequent ones. Those individuals who are not sensitive to bed bug bites may not know they have an infestation. Because bed bugs are nocturnally active, it's hard to see other signs of their presence—unless you're accustomed to waking up at 3 A.M. and taking a census. With a huge infestation, bed bugs start to move away from the bed, so you're more likely to see one in an exposed place during the day. In very severe infestations people can become anemic. That takes a lot of bugs though—maybe 100,000 feeding once a week or more.
Individual responses to bites vary, ranging from no visible effect (in about 20–70%), to small macular spots, to prominent wheals and bullae formations along with intense itching that may last several days. The bites often occur in a line. A central spot of bleeding may also occur due to the release of anticoagulants in the bug's saliva.
Run hot water as hot as you can take it. When its hot enough for you, run the hot water over your bites. Yes it does burn a little, but you’ll feel relief from the hot water drawing the “itch” out. Do this for about 10-15 seconds and then immediately switch to very cold water and run that over it. The shock to your skin from going from hot to cold immediately relieves the itch and it lasts for hours. I can take it pretty hot, so I almost give myself burns, but its worth it.
Often, bedbug bites are clustered along lines usually following arms and legs. Theories range from the idea that bedbugs are feeding along blood vessels to the idea that bedbugs remain with their bodies touching the bedding while they feed, and the bugs are left to feed only along lines where the skin is touching the bedding in just the right manner.
One bed bug will usually take more than one bite. Once a bed bug inserts its mouthparts and finds a suitable blood vessel, it will begin feeding. However, finding the right blood vessel may take more than one injection into the skin. In addition, bed bugs are very sensitive to movement by the host they are feeding on. Therefore, if a sleeping person moves, a feeding bed bug will probably withdraw its mouthparts and begin its search for a blood meal on another part of the body. It’s important to remember that the number of bites a person receives is not indicative of the number of bed bugs that feed on that person.