Each of the following pictures of bed bug bites shows typical skin reactions to the insect's saliva. Most people  are not hypersensitive to the bites and will show no reaction at all with the exception of two small dots where the bedbug punctured the skin. Other people can develop red papular eruptions (raised inflamed areas) or in severe cases, blisters.
I’ve cleaned the entire area…this time sprayed it all down with a bedbug killing spray (Raid). Everything, nooks, crannies, corners, the vent. I’ve also re-inspected my spare mattress. No sign of anything. I’ve gone as far as going into both. the inside of my boxspring has been saturated with the raid spray as is the “down” side of the mattress. I slashed into the side of the mattress and sprayed inside there too. I am going to be mopping with bleach in the morning and afterward I will do my spray down again.
The size of bed bug bites varies with a number of different factors. Bed bugs inject an anti-coagulant along with their saliva when they pierce the skin to take a blood meal. This anti-coagulant is mostly responsible for how a person reacts to the bite and determines the size of the bug’s bite. Since people will have various sensitivities to the bed bug’s bite, the size of the bite will vary, as well. Another factor that influences the size of a bed bug reaction is the number of times a person is bitten. Bite reactions of people bitten many times are also variable, and their response may be either more or less intense as the number of bites increases.
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