Bedbug bite reactions are self-limited and typically resolve within one to two weeks without intervention.15 There is no evidence that any treatment alters the natural history of bedbug dermatitis.8 If pruritus is present, nonprescription topical antipruritic preparations containing the active ingredient doxepin, or intermediate potency corticosteroids may be beneficial. Mupirocin (Bactroban) and/or systemic antibiotics should be considered in the treatment of superinfected bites.8
If all other options have been exhausted, you may need to seek a professional PMP (Pest Management Professional). There are pesticides that are approved for professionals to use during a infestation. These pesticides, however, are not always effective, and typically not as effective as steam cleaning, excessive heat, or excessive cold. The exterminator may opt to treat the area with carbon dioxide.

Diagnosing bed bug bites can be hard for medical professionals. We often hear of doctors assuming a variety of skin conditions before bed bugs – especially doctors who haven’t encountered patients with bed bug bites before. While there is no specific test to determine whether bites are from bed bugs there are tests that can show whether or not it’s an insect bite. This is useful for ruling out issues like eczema or allergic reactions, but not for determining that any specific insect bite is a bed bug. To be sure you’ll want to check for other signs of bed bug infestation, such as the bugs themselves, moltings, and the characteristic staining of their blood meal feces.
I am having a severe allergic reaction to bed bug bites and I’m 3month pregnant. So bad first they are hives that turn in blisters even on my eye lid, on the top of my hand and on my lower back, I’ve taken benedrel which only gives me about an hr of relief, then it returns and hives last for days. I’m debating going to er, how do they treat this when you’re pregnant?
As mentioned earlier, applying insect repellent at bedtime will probably not deter bed bugs from biting. When working in severely infested dwellings, there may be some benefit to spraying tops and bottoms of shoes with DEET-based repellents. Those working in bed bug-infested environments may also want to hot wash or run clothing, etc. through a dryer upon returning home or to the office.    
After a few minutes of hot water therapy, use cool water on the bites. You may alternate hot and cool water several times until itching is minimal or gone. Finish with cool water and apply aloes to bites. You will have several hours of relief. My doctor told me the hot water releases the histamine in the skin glands and it tales several hours to refill the glands. About bee stings: I had a extreme reaction to one wasp sting several years ago. Last year I was attacked and suffered over 60+ bites on my face, neck and upper body. I raced into the house and jumped into to shower and opened the hot water full blast.
When traveling, inspect the bedding prior to exposing yourself or your belongings. Seal your dirty clothes in plastic bags. You may even consider encasing your luggage in a plastic bag while you are in a hotel room. Launder your clothing as soon as you get home. You can treat your suitcase by vacuuming, using a clothes steamer, or handwashing it with hot water and soap. You might also consider encasing luggage in a plastic bag between trips.
The bites themselves don't usually pose any major health risk since bedbugs are not known to spread diseases, but an allergic reaction to the bites may require medical attention, CDC officials say. There have also been some strange cases linked to bedbug infestations. Researchers reported in the Canadian Medical Association Journal in 2009 that they treated a 60-year-old man for anemia caused by blood loss from bedbug bites. Another study published in 1991 in the Journal of the Egyptian Society of Parasitology found that people with asthma might be more susceptible to allergic reactions from bedbug bites.
Unlike those of other insects, bed bug bites may sometimes appear in tight lines of multiple, small, red marks where multiple bed bugs have fed along an exposed area. Bed bug bites can cause itchiness. Initially, a victim may detect a slight burning sensation. The burning area then develops red bumps, known as papules or wheals (rash). In extreme cases, bites may swell dramatically or turn into blister-like skin inflammations.
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