Cutaneous reactions to bedbug bites can vary widely and are easily confused with other conditions (Table 1).15–19 A typical lesion is a 2- to 20-mm, pruritic, erythematous maculopapule with a central hemorrhagic crust or vesicle.5,8 Macules, papules, wheals (Figure 3), vesicles, bullae, and nodules have all been reported,20 as have asymptomatic lesions with a barely visible punctum as the only evidence of a bite.8 Bites vary in number and are preferentially distributed in unclothed areas (e.g., face, neck, extremities). Unlike many other arthropod and insect bites, bedbug bites are rarely located in the popliteal fossae or axillae.21 Lesions can be noticeable immediately when waking up or several days later, with the reaction often progressing from delayed to immediate with subsequent exposures22–26  (Table 2). The classic bedbug rash is referred to as “breakfast, lunch, and dinner” because it commonly presents as several bites in a row or cluster 20 (Figure 4).

"In the past, bedbugs have repeatedly shown the ability to develop resistance to products overly relied upon for their control. The findings of the current study also show similar trends in regard to chlorfenapyr and bifenthrin resistance development in bedbugs," study researcher Ameya Gondhalekar, research assistant professor at Purdue's Center for Urban and Industrial Pest Management, said in the Entomology Today statement. "With these findings in mind and from an insecticide resistance management perspective, both bifenthrin and chlorfenapyr should be integrated with other methods used for bed bug elimination in order to preserve their efficacy in the long term."

The bites do not usually require medical treatment. Secondary bacterial infection of the skin may develop in areas that become irritated due to prolonged scratching. Topical antibiotic creams or ointments may relieve symptoms of a secondary infection. Antiseptic lotions may also be beneficial. If you've had an allergic reaction to the bedbug bites, your doctor may recommend oral antihistamine medications or corticosteroids.
Hey there! So I recently stayed in a condo through a timeshare. After two nights of staying there I woke up with about 30 bites all over my boxy (head to toe) throughout the day more and more bites appeared. They have began to itch very, very badly and are now beginning to blister. I did go to a nearby lake as well so it could possibly be something from the lake. I went to two separate physicians and neither one of them could diagnose the bites as anything. I am no longer there to inspect the bedding and furniture, unfortunately. Although I didn’t not see any blood spots, egg shells or any of that matter on the bed sheets. Do you think the bites could be from bed bugs?
We recently moved to Chicago into an apartment building. AFTER signing the lease the landlord told us that he sprayed for bed bugs every 3 months…I guess I thought this was precautionary? It wasn’t. I am apparently allergic to these bites, my husband & son, thank god, are not affected. So far nothing helps me with the itch for more than a minute but I just found this sight so hopefully something will work. We have bug bombed and bug sprayed with no luck. Washing everything helps for maybe a day? Tonight we sprayed bleach ALL OVER our mattress and attacked it with a blow-drier. Also, I’ve slathered myself in baby oil per a post here.
We took a road trip with our kids, stayed in a nice hotel and guess what? Bed bug bites on all of us. I usually carry a product with us as it works on insect bites so we decided to try it… thank goodness it worked and got rid of the pain and itching quickly… i ordered it from a website but soon found out that I could do the same thing with baking soda and water as mentioned on this site. Before you buy, consider the alternatives! Thanks and good luck to everyone!
According to textile experts (Drycleaning & Laundry Institute, Laurel, MD), most garments designated as ‘dry-clean only’ (e.g., cotton, wool, silk, linen, rayon, nylon) will not be harmed provided they are dry before being placed in a clothes dryer at a moderate temperature setting. Dry cleaning procedures also kill bed bugs, but there is a risk of infesting the establishment when buggy items are tagged and sorted. 
Bites on dogs and cats will look much like bites on people, and the pet owner may actually suspect a mosquito or flea bit the pet. As with people, bed bugs do not stay on pets, but return to a protected harborage site after feeding. In addition to bites, the presence of the bug’s feces, cast skins and the animal’s irritation at night are also indicators of bed bugs biting pets. Therefore, one of the best things to do is inspect the pet’s bedding and frequently groom the animal while being vigilant for the telltale signs of bed bug presence.
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