If you know that you have the bugs. Get sealing covers the kind that encloses completely, one for the mattress and one for the box spring. That will trap those critters inside and they will eventually die in there. Next you will need to decide of what combination of treatments you wish to use. Its a job that you will have to keep up with for some time. Do your research online first.
Cracks and crevices of bed frames should also be examined, especially if the frame is wood. (Bed bugs have an affinity for wood and fabric more so than metal or plastic.) Wooden support slats, if present, should be removed and examined since bed bugs often congregate where the ends rest on the frame. Screw holes, knots and other recesses are also common hiding places. Headboards secured to walls should be removed and inspected. In hotels, the area behind the headboard is often the first place that bed bugs become established. Bed bugs also frequently hide within items stored under beds. 
“Good night, sleep tight, don’t let the bed bugs bite.” This horrific nighttime creature is a member of the Hemiptera order of insects that feast solely on blood. Because of the way they mate, they multiply in size while breeding. A Department of Health report claimed that if forty are placed in a room with a mild temperature, within six months their population would exceed 5,900.
A common concern with bed bugs is whether or not they transmit diseases. Although bed bugs can harbor various pathogens, transmission to humans has not been proven and is considered unlikely. Their medical significance is most commonly attributed to itching and inflammation from their bites. Antihistamines and corticosteroids may be prescribed to reduce allergic reactions, and antiseptic or antibiotic ointments to prevent infection. Though not known to carry diseases, bed bugs can substantially reduce quality of life by causing discomfort, sleeplessness, anxiety, and embarrassment. According to some health experts, the added stress from living with bed bugs can have a significant impact on the emotional health and well-being of certain individuals. 
Help!! I have had a long and exhausting experience with these nasty bugs. My mother in law had stayed at my house for a few nights and a few weeks later after returning home she discovered she had a severe infestation of bed bugs.. so of course I took precautions at my home thinking she gave them to me. I threw my mattress away then taped off my entire bed with very sticky tape. No signs or bites at all . Then a few weeks later my son started to sleep in his bed again and sure enough he woke up with 3 bites in the shape of a triangle that were swollen and itchy. I searched his bed and found a casing shell and 3 blood stains under his box spring .I called a exterminator he came out and said we had a mild infestation and there was no signs in my bed but he found one live bug in my son’s bed. He treated the bedrooms and living room. Then my son and i were getting these little bumps on our body that looked nothing like the triangle bites and didn’t itch so the exterminator came again and treated but found no evidence of bed bugs and this cycle happened four times! So he has treated my apartment 4 times and found no signs of bed bugs and even had a dog come out to sniff around .. this was all over the course of about 5 months . The exterminator insists that we do not have bed bugs anymore but my son is still getting these bumps on him, some are reds dots and some are skin colored but no complaining of itching . I’m very overwhelmed and exhausted and havery no idea what to think. I think the tape on my bed prevented them from getting back into my bed after I threw my mattress out but again the exterminator said tape does not work. Are they hiding somewhere else like in the walls to where the exterminator think the problem is gone ?
Avoiding bed bugs is most challenging in hotels, apartment buildings, and other places where there are many people, high turnover and ongoing opportunities for introduction of the pests. Periodic, preventive inspection by tenants, housekeeping/maintenance staff, or pest control firms is the best way to detect infestations in their initial stages when they are easiest to control. Visual inspections can be supplemented by using various monitoring devices to capture and reveal bed bugs that may have been overlooked by occupants.   
Bed bugs occur around the world.[36] Before the 1950s about 30% of houses in the United States had bedbugs.[2] Rates of infestations in developed countries, while decreasing from the 1930s to the 1980s, have increased dramatically since the 1980s.[3][4][36] Before the 1980s they were common in the developing world but rare in the developed world.[4] The increase in the developed world may have been caused by increased international travel, resistance to insecticides, and the use of new pest-control methods that do not affect bed bugs.[37]
Hi there! Honestly, if you have checked properly (like really well) and you don’t see any signs of bed bugs, it might be another insect. Unfortunately, there are so many little insects that could be biting you (such as fleas, etc.) but maybe start with giving all your laundry a good hot wash. Once that is done, see if you continue getting the bites and then we can investigate. Good luck, if you appreciated my help, please share my blog with your friends and family.
This pair of bed bug bite photos below show the immediate (left) and next day (right) reaction after feeding a colony of bedbugs from a container in the lab. (That's why they are contained in a small circular area).  The hive-like immediate symptoms are replace by dark red rash type reaction the following day with inflammation and less severe redness radiating out to a larger area.  
I am 59 and never had any allergies before.. My other half never got bit until recently, and it is only recently I’ve seen the bugs.. we got a new kittie and he gets them before or after they get me. That’s how I finale got to see one, he woke me up chasing it..the bites I cover with alcohol for 2-3 days, the itching stays down… am going to try the Diatomaceous earth trick, am on a small pension and can not afford Orkin or any others..love this site, great information..
Amazingly, these sneaky little bloodsuckers dine on you without waking you. You don't feel their stealthy bite because they inject a numbing agent into your body, along with an anticoagulant to keep your blood flowing as they suck. The first sign of bedbugs may be itchy, red bites on the skin, usually on the arms or shoulders. Bedbugs tend to leave straight rows of bites.
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