Bed bug bites typically appear in groups of three, called the "breakfast, lunch, and dinner" pattern. Each victim's reaction to bed bug bites is unique. Some may have a slight reddening of the skin. Others may have a more severe reaction, causing a raised, itchy rash. A raised rash may obscure the individual bites, making it challenging to identify. Sometimes, bites and lesions can throb and become very painful for days after the bugs bit you.

Blood spots found on one’s sheets, bites and the presence of bed bug feces and cast skins are some of the indications of a bed bug infestation. Bites are commonly found on the parts of the body that are more likely to be exposed to bed bugs during sleep – the hands, neck, face, shoulders, legs and arms. While not always the case, bed bug bites are often grouped together in a small area and at times may occur in a line or a zigzag pattern. Bites normally look like small, flat or raised areas that may become inflamed, itchy, red or blistered. Bed bug bite reactions don’t always appear immediately after you’re bitten and may take a few days to begin causing symptoms. However, not everyone reacts to bed bug bites in the same manner.
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