Bed bugs often hide in seams, folds and crevices of mattresses, box springs, bed frames and headboards. A thorough inspection requires dismantling the bed so that upper and lower seams and surfaces can be examined. Things to look for are the bugs themselves, shed skins of the nymphs (immature bed bugs), and the blackish fecal spots. The dark spots of dried bed bug excrement are often present along mattress seams or wherever the bugs have resided. Box springs afford many places for bed bugs to hide, especially along the upper seams and underneath, where the bottom edge of the box rests on the frame. If an underlying dust cover is present, it may have to be removed to gain access for inspection and possible treatment. Successful treatment of mattresses and box springs can be difficult, however, and infested ones may need to be discarded or encased in a protective cover.
Most bites will have a small clear area in the center surrounded by redness that may or may not be raised. People tend to become more sensitive and have larger reactions after each episode. Reactions can include itch, swelling, rash and wheals (large round red area on the skin). Severe reactions can cause skin blisters and trouble breathing, although these reactions are very rare.
To prevent bringing bed bugs to one's own home, travelers are advised to take precautions after visiting an infested site: generally, these include checking shoes on leaving the site, changing clothes in a garage before returning to their home, and putting the used clothes in a clothes dryer outside the house. When visiting a new lodging, it is advised to check the bed before taking suitcases into the sleeping area and putting the suitcase on a raised stand to make bedbugs less able to crawl in. "An extreme measure would be putting the suitcase in the tub." Clothes should be hung up or left in the suitcase, and never left on the floor.  The founder of a company dedicated to bedbug extermination said that 5% of hotel rooms he books into were infested. He advised people never to sit down on public transport; check office chairs, plane seats and hotel mattresses, and monitor and vacuum home beds once a month.
I am staying at A up scale hotel where they are charging me top dollar to be attacked in my sleep. I am waiting for the hotel management so I can introduce him to my new hostage (bed bug). I woke up at six and pulled back the sheets and there it was one of my knight time terrorist. They ate me like I had cherry flavored lotion. I HAVE TO WARE PAINTS TODAY AND ITS HOT. I AM NOT HAPPY. So how to treat bed bug bites like this, what lotion works best?
Scrub infested surfaces with a stiff brush to dislodge eggs. Vacuum the room extensively. Use a vacuum hose attachment to thoroughly vacuum cracks and crevices on furniture and along baseboards on the walls. Vacuum along baseboards, furniture, bed stands, rails, headboards, foot boards, bed seams, tufts, buttons, edges of the bedding, as well as the edges of the carpets (particularly along the tack strips). A good vacuum cleaning job may remove particles from cracks and crevices to encourage greater insecticide penetration. Bed bugs cling tightly to surfaces, so it is best to vacuum by scraping the end of the vacuum attachment over the infested areas to pull out the bed bugs. Caution: It is not good to use a bristle attachment, because you may transfer bed bugs to other areas since they cling to the brush. Dispose of vacuum cleaner bags after you are finished in an outdoor trashcan.
One bed bug will usually take more than one bite. Once a bed bug inserts its mouthparts and finds a suitable blood vessel, it will begin feeding. However, finding the right blood vessel may take more than one injection into the skin. In addition, bed bugs are very sensitive to movement by the host they are feeding on. Therefore, if a sleeping person moves, a feeding bed bug will probably withdraw its mouthparts and begin its search for a blood meal on another part of the body. It’s important to remember that the number of bites a person receives is not indicative of the number of bed bugs that feed on that person.