Hey Ruth! If there are absolutely no signs of bed bugs (upon close inspection), its unlikely that they are the cause for the bite marks. I recommend taking another look for dark brown marks (dried blood) and other signs of their presence. Regardless, if you want to kill any bug on that mattress, just get a handheld steamer and blast it. The heat will kill everything and its completely natural. Hope that helps!
When it comes to controlling bed bugs, "do it yourself" should not be anyone's motto. Bed bugs are notoriously difficult to eradicate - 76 percent of pest professionals say they are the most difficult pest to control.  As such, people who suspect a bed bug infestation should turn to a qualified pest professional with expertise in treating these pests. The pest professional will evaluate the extent of an infestation and recommend the best course of treatment.  In fact, the Centers for Disease Control and Prevention endorses that appropriate control of a bed bug infestation requires an experienced pest management professional and recommends that victims be advised against attempting to control measures themselves.
Insect and spider bites and how to deal with them Insect and spider bites can occur almost unnoticed, or they can be painful. Either way, home treatment is usually enough for most symptoms. However, some bites can spread serious disease, such as Lyme disease and malaria. Find out how to protect against bites and what to do if someone has a severe reaction to a bite. Read now
Bed bugs are small, brownish, flattened insects that feed solely on the blood of animals. Although the common bed bug (Cimex lectularius) prefers feeding on humans, it will also bite other warm-blooded animals, including dogs, cats, birds and rodents. It has done so since ancient times; bed bugs are mentioned in medieval European texts and classical Greek writings back to the time of Aristotle.
Don't assume your bites are bedbugs. Bites can be hard to identify, even for doctors. Rule out mosquitoes, fleas, mites, and biting gnats by conducting a visual inspection. It's best to collect and identify bedbugs to confirm bites. Look for the bugs themselves or their bloodstains, especially along the seams of mattresses. Further, look for dark spots of insect waste where bedbugs might crawl into hiding places on furniture, walls, and floors.
Bed bugs (Cimex lectularius) are small, flat, parasitic insects that only feed on the blood of humans and animals while they sleep. They are reddish-brown in color, about 1mm to 7mm in size, and can live for several months without a blood meal. Bed bugs are not known to spread diseases, but their presence can cause itching and loss of sleep. Excessive scratching can increase the chance of secondary skin infections. Bed bugs are found all over the world and the cleanliness does not determine the presence of bed bugs.
Traditional methods of repelling and/or killing bed bugs include the use of plants, fungi, and insects (or their extracts), such as black pepper;[54] black cohosh (Actaea racemosa); Pseudarthria hookeri; Laggera alata (Chinese yángmáo cǎo | 羊毛草);[15] Eucalyptus saligna oil;[55][56] henna (Lawsonia inermis or camphire);[57] "infused oil of Melolontha vulgaris" (presumably cockchafer); fly agaric (Amanita muscaria); tobacco; "heated oil of Terebinthina" (i.e. true turpentine); wild mint (Mentha arvensis); narrow-leaved pepperwort (Lepidium ruderale); Myrica spp. (e.g. bayberry); Robert geranium (Geranium robertianum); bugbane (Cimicifuga spp.); "herb and seeds of Cannabis"; "opulus" berries (possibly maple or European cranberrybush); masked hunter bugs (Reduvius personatus), "and many others".[58]

When I discovered bed bugs, at first I thought it was just mosquitoes or something. It wasn’t they his exceptionally well. I cleared any clutter I had, especially near the bed. How to Treat Bed Bug Bites, or bugs in general is you need to first inspect the bed. The black dots are a sign where they dwell. You need to be careful not to alarm them or they’ll just move to another location that’s harder to find.

I am apparently allergic to these things. My bites swell to huge sizes and I get red marks running up my arms and it itches like crazy, almost like a burning itch. However, doing some research I found an effective way to stop the itch. Its not for everyone, but for someone like me who can’t even touch the shells (my fingers have gotten swollen searching for the damn things), this works for me. Again, not for everyone:
Bed bug bites can look a lot like other insect bites. Some clues that can suggest the presence of bed bugs include finding red, itchy bites upon awakening - especially if the bites line up in a row on the skin. Bed bugs typically bite at night on exposed areas of skin, so the bites are most commonly found on the face, neck, hands and arms. Although some people develop a bite reaction immediately, others may take two to three days before a reaction becomes noticeable, and not all people have obvious bed bug bite symptoms. A bed bug bite can appear as a tiny puncture wound without a surrounding reaction, and can easily be missed. In fact, 30 percent of individuals living in bed bug-infested dwellings report a lack of bites or skin reactions. This appears to be more common amongst the elderly. On the other hand, other people have exuberant reactions, with large, red, raised and itchy welts. This is especially true if one becomes sensitized to bed bug bites, so that with repeated bites there is an increased risk of an exaggerated reaction to bed bug bites.

No two people react to bites in the same way, although some reactions are similar. Because of the saliva that they leave behind, the first reaction is usually severe itching and irritation. This is often followed by a raised appearance on the contacted area. Some people, however, react by having welts and hives all over the body. Still others will have small, pinkish bumps that are concentrated in one area.
We kept feeling something crawling on us when we sat on tge couch. Then tiny bites Started appearing. After months of trying various cleaning approaches, we contacted Terminex. Their inspector found two bedbugs in the seams of a chair in the bedroom , but nothing on the sofa. They charged me a thousand dollars and steam cleaned both the bed, chair and sofa. About 10 days later, we started getting bites again. Terminex came and “dusted” the areas thus time. This continued for a a few months and them the “inspector” from Terminex said they could fund no signs of the bugs rhe last few times and he thought misquitoes were probably biting us. It has been months now and the problem has worsened. Now I get horrible welts when bitten and we constantly look for tangible signs: excrement, bugs in tape, anything before we call a different extermination company but life has become unbearable. We can’t have guests over because we fear they’ll become infected. It has been and is a truly awful experience.

Avoiding bed bugs is most challenging in hotels, apartment buildings, and other places where there are many people, high turnover and ongoing opportunities for introduction of the pests. Periodic, preventive inspection by tenants, housekeeping/maintenance staff, or pest control firms is the best way to detect infestations in their initial stages when they are easiest to control. Visual inspections can be supplemented by using various monitoring devices to capture and reveal bed bugs that may have been overlooked by occupants.   
Since bed bugs can be found throughout the world, many people have suffered from their bites. Since you are reading this, you have also most likely been a victim but don’t worry, you are not alone. Their primary diet is blood, which makes humans their meal of choice, definitely not good news for us! Based on personal experience, they can leave a rather nasty, red mark which can itch like mad. No wonder people say “Goodnight and don’t let the bed bugs bite!” What do these bites look like (and what to do if you are bitten) and what are some ways that you can get rid of them?
Hey I went to visit friends this Saturday and Sunday. Saturday I slept fine Sunday I slept in a different location, I kept feeling bites but was unsure through the night. I woke up the next morning with red bumbs like two clusters of three and four on one arm, four on my other arm not far apart, four on my leg, three on my lower back. As they day went by they got bigger like lumps and really itchy, I had benedryl and creme I could not sleep last night at all. Some of them hurt a bit I try not to scratch them. Ooh and three on my face, my skin is very sensitive, my friends sat on the same chair I sleep on noone got bit. How long does the itching last, Iaautomatically knew it had to be bed bugs does it sound like them??

i found some thing that works i put a heavy blanket against the couch and then use itching cream called gold bond medicated cream use the maximum kind use it on every part u have been bitten do this for a while u will start to see a change the bites will start to go away slowly until they r all gone also make sure to wash where ever you have been bitten in cold water and use a lot of soap wash them good then use the medicated cream just some tips i have bed bugs and i have been bitten and it sucks it itches bad but i have found that this works!

I recently just got bed bugs from my room mates moms house and the pain is so bad it to me feels like there’s poison in my stomache and it sucks. i have done the benadryl spray didn’t work the only thing that i been doing that helps with the itch is the rubbing alcohol, but the thing is it works but for like ten mins and that’s it. Tonight i am hopefully hopping to try the lime thing and see how it goes will keep an update.
Items that cannot be placed in a washer or dryer can sometimes be de-infested by wrapping them in plastic and placing them outdoors in a hot, sunny location for at least a day (for example, on pavement or in a closed vehicle parked in the sun). Packing items loosely in garbage bags and elevating objects off the ground helps the heat permeate further, and will make it harder for bugs to find a cool place to hide. Monitoring with a thermometer is prudent to ensure that a temperature of at least 120°F is achieved wherever the bugs may be. 
Around the time I started getting bites, I noticed more and more neighbors throwing out mattresses, furniture… I got suspicious. We live in apartments. I react differently to different kinds of bites so I can always tell the difference between mosquitoes and ants and such. I didn’t know what those bites were until I caught one of the little hellions crawling across the sheets.
The bites do not usually require medical treatment. Secondary bacterial infection of the skin may develop in areas that become irritated due to prolonged scratching. Topical antibiotic creams or ointments may relieve symptoms of a secondary infection. Antiseptic lotions may also be beneficial. If you've had an allergic reaction to the bedbug bites, your doctor may recommend oral antihistamine medications or corticosteroids.
Amazingly, these sneaky little bloodsuckers dine on you without waking you. You don't feel their stealthy bite because they inject a numbing agent into your body, along with an anticoagulant to keep your blood flowing as they suck. The first sign of bedbugs may be itchy, red bites on the skin, usually on the arms or shoulders. Bedbugs tend to leave straight rows of bites.
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