Avoiding repeated bites can be difficult, since it usually requires eradicating bed bugs from a home or workplace; eradication frequently requires a combination of pesticide and non-pesticide approaches.[3] Pesticides that have historically been found to be effective include pyrethroids, dichlorvos and malathion.[4] Resistance to pesticides has increased significantly over time and there are concerns of negative health effects from their usage.[3] Mechanical approaches such as vacuuming up the insects and heat-treating or wrapping mattresses have been recommended.[3]
A common concern with bed bugs is whether or not they transmit diseases. Although bed bugs can harbor various pathogens, transmission to humans has not been proven and is considered unlikely. Their medical significance is most commonly attributed to itching and inflammation from their bites. Antihistamines and corticosteroids may be prescribed to reduce allergic reactions, and antiseptic or antibiotic ointments to prevent infection. Though not known to carry diseases, bed bugs can substantially reduce quality of life by causing discomfort, sleeplessness, anxiety, and embarrassment. According to some health experts, the added stress from living with bed bugs can have a significant impact on the emotional health and well-being of certain individuals. 
One trick to make this disposal easier involves using the cut-off end of a nylon stocking (or a knee-high nylon stocking) and a rubber band. Insert the stocking (toe first) into the end of the vacuum suction wand/tube, leaving the opening of the stocking protruding out of the end of the suction wand. Then fold the stocking opening back over the end of the wand and use the rubber band to secure it there. When the vacuum is turned on and the bed bugs are sucked into the tube, they will be trapped in the stocking. Afterwards, carefully remove the rubber band and retrieve the bug-filled stocking. Then secure the end of the stocking with the rubber band and dispose of it. 

Some of the dusts that are available to consumers, such as diatomaceous earth, can help in this regard. Pest controllers will put dusts in wall voids and other places where pesticide won't reach. What happens is the bugs will wander through the dust and pick up particles and be more vulnerable to desiccation after that exposure. But dusts will not solve the problem if deployed incorrectly, and if they are applied at too high a level they can cause breathing difficulties in some people.

A common concern with bed bugs is whether or not they transmit diseases. Although bed bugs can harbor various pathogens, transmission to humans has not been proven and is considered unlikely. Their medical significance is most commonly attributed to itching and inflammation from their bites. Antihistamines and corticosteroids may be prescribed to reduce allergic reactions, and antiseptic or antibiotic ointments to prevent infection. Though not known to carry diseases, bed bugs can substantially reduce quality of life by causing discomfort, sleeplessness, anxiety, and embarrassment. According to some health experts, the added stress from living with bed bugs can have a significant impact on the emotional health and well-being of certain individuals. 
Just wondering if it is unusual for bed bugs to bite where you are clothed? I have 3 bites, in a diagonal line on one side and in a triangle shape on the other side of my pelvic area both which are covered by underwear at night. Then I have a random spot here and there on my legs. We have a plastic mattress cover on our bed but use dark sheets. As best I can tell there is no evidence of bed bugs. What do you think? Thanks!
Data Sources: A PubMed search was completed in Clinical Queries using the key terms bedbug, rash, bites, and infestation. The search included meta-analyses, randomized controlled trials, clinical trials, case reports, and reviews. We also searched the online databases of the Environmental Protection Agency, Centers for Disease Control and Prevention, and Jefferson Clinical Images. Lastly, we used Essential Evidence Plus. Search dates: February through June 2011.
One bed bug will usually take more than one bite. Once a bed bug inserts its mouthparts and finds a suitable blood vessel, it will begin feeding. However, finding the right blood vessel may take more than one injection into the skin. In addition, bed bugs are very sensitive to movement by the host they are feeding on. Therefore, if a sleeping person moves, a feeding bed bug will probably withdraw its mouthparts and begin its search for a blood meal on another part of the body. It’s important to remember that the number of bites a person receives is not indicative of the number of bed bugs that feed on that person.
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