You can develop a skin infection if you scratch the bites. Rarely, a more severe allergic reaction to the bites could produce larger welts, blisters, or anaphylaxis. Bedbugs may also trigger asthma attacks and getting too many repeated bites could lead to anemia. Anxiety, insomnia, and sleep disturbances are common due to the stress of discovering bedbugs.
Bring a little flashlight—hotel room lighting is always pretty poor and the dimmer the lighting, the harder it is to see small bed bugs or their fecal spots. I would pull back the bed covers and look all around the head of the bed. Pull back the sheets, too, and look at mattress seams and edges that are exposed. bed bugs love to hide under mattress tags. Look all around the box springs, too. If there's a dust ruffle, pull it up and look under it as much as possible. Look for moving bugs and stationary, hiding bugs.

Cutaneous reactions to bedbug bites can vary widely and are easily confused with other conditions (Table 1).15–19 A typical lesion is a 2- to 20-mm, pruritic, erythematous maculopapule with a central hemorrhagic crust or vesicle.5,8 Macules, papules, wheals (Figure 3), vesicles, bullae, and nodules have all been reported,20 as have asymptomatic lesions with a barely visible punctum as the only evidence of a bite.8 Bites vary in number and are preferentially distributed in unclothed areas (e.g., face, neck, extremities). Unlike many other arthropod and insect bites, bedbug bites are rarely located in the popliteal fossae or axillae.21 Lesions can be noticeable immediately when waking up or several days later, with the reaction often progressing from delayed to immediate with subsequent exposures22–26  (Table 2). The classic bedbug rash is referred to as “breakfast, lunch, and dinner” because it commonly presents as several bites in a row or cluster 20 (Figure 4).
I can definitely understand. This is has been going on with us for almost a year. My hands and arms look like I have leprocy or something. Horrible blisters, rash, scabs, and bunches of “bumps” especially in my right hand. I wind up with painful blood blisters some times. I am living on benedryl and calamine lotion. I hate going out because of what I look like. I have taken to using cover up and foundation on my hands to make the mess less noticable. i have a long-sleeved summer weight sweater that I wear whenever I do have to go out.
We have bedbugs. They are all over the house. In all of the rooms. My daughter feels that it would be safer to sleep outside than in this house. My son has really sensitive skin and the bedbugs love to attack him. One night he just kept twisting and turning because he must have been itching. We have had to get rid of all of our beds and have had to sleep on the floor. The floor is safer than the beds but not by much. The bedbugs seem to be everywhere. On the walls, on the floor, with you, or in your beds. We have tried many things so if anyone has any advice, it would be very much appreciated.
Unlike those of other insects, bed bug bites may sometimes appear in tight lines of multiple, small, red marks where multiple bed bugs have fed along an exposed area. Bed bug bites can cause itchiness. Initially, a victim may detect a slight burning sensation. The burning area then develops red bumps, known as papules or wheals (rash). In extreme cases, bites may swell dramatically or turn into blister-like skin inflammations.
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