Hello all I just want to put this out there that heat is the best way to kill these little pests. I work for a company that uses heat to do structural pasteurization, in other words we heat the entire house up to 140°+ (which is higher than the the thermal kill point for bedbugs) for an hour or more (though they can only withstand that heat for less than 15 min) This has been the ONLY way to kill them with a 100% success rate since they are becoming resistant to chemicals and DDT is illegal. Some things work for some infestations but not for all, there are a lot of good ideas on here :-)

Bed bugs usually bite people at night while they are sleeping. Hungry bed bugs may also feed during the daytime, especially if this is when the occupant normally sleeps. They feed by piercing the skin with an elongated beak through which they withdraw blood. Engorgement of the bed bug takes roughly three to 10 minutes, but because the bite is painless, the person seldom realizes they are being bitten. Bed bugs normally do not reside on people like head or body lice do; instead, immediately after feeding, bed bugs crawl to a secluded location to digest their meal. Symptoms after being bitten by bed bugs vary from person to person. Many develop an itchy red welt within a day or so of the bite. Others have little or no reaction. Sometimes the reaction is delayed days or even weeks after the actual bite occurs, which can make it difficult to determine where or when bites actually occurred. Studies conducted in bed bug-infested apartments suggest about 30 percent of people do not react even when bitten repeatedly over time, and there is still higher incidence of non-reactivity among the elderly. Unlike flea bites, which occur mainly around the lower legs and ankles, bed bugs feed on any skin exposed while sleeping (face, neck, shoulders, back, arms, legs, etc.). The welts and itching are often wrongly attributed to other causes, such as mosquitoes. For these reasons, infestations may go a long time unnoticed, and can become quite large before being detected. 
After being treated by a dermatologist for nearly 2 mos for red marks all over my body – he stated that I did not have bed bug bites (he even took a biopsy of my skin) and said I had leichen planus. I took pills for 2 weeks and then began ultra violent light treatments – nothing was helping them go away. Finally, I called an exterminator to inspect my home only to find out we have bed bugs and the marks on my body are bed bug bites. I stopped going to the dermatologist and wasted 2 months precious time in getting rid of the bugs. They are driving me crazy – had my first extermination done (2 more needed) and still seeing the bugs and getting bit – can’t sleep a wink – any suggestions to help with the anxiety I’m going through would be greatly appreciated.
8 days ago my friend & i decided to crash at my grandmas house after a wild night out. in the morning we woke up in horror seeing how they freely crawled all over her mattress cover. Within the last 7 days, bite marks have been appearing all over my body, i am practically covered; as to my friend, well lucky her she has only 3 on her arm. The problem isn’t only that i have more bites than her but i believe i have an allergic reaction, the bites have massively grown in size. I do not know what else to try, Calamine doesn’t work, baking soda with water made it worse, Benadryl hasn’t done anything either. I am at a point where i am about to cry. The worst part is that in less than a month I am going on my first tropical vacation. I simply cannot handle the stress, i suffer from mild anxiety & these massive rashes have turned these 7 days into hell. I have stopped scratching because it seems to irritate the bites. Please help.
Kept replacing the sticky traps just in case but never caught anything other than the occasional spider. Always cycled the sheets and such using the car+sun. They were still getting to us. Bed bugs cannot fly or jump. They had to be in the bed frame. I check it over and notice rusty spotting, which is apparently bed bug fecal matter. Luckily ours was from IKEA so it was easy to take apart – and sure enough – there they were. The way my bed works is a metal frame with holes, rubber end caps fit into those holes, and wooden slats run across the frame in the end caps. So every few days I’d mix up a 50/50 mix of bleach and water in a bucket and soak the wooden slats and end caps for ten minutes. The bed bugs were gone a couple of weeks and came back. I started soaking the things longer and scraping them with a disposable spoon, which was hard to do on the end caps. It warped the wood a little but nothing too bad. After a couple of weeks or so, I stopped finding bed bugs in the frame. I was worried they were in the metal too, but I completely stopped getting bites. I think the added time and scraping got rid of eggs. Not a lot can survive a 30 minute bleach bath.
No one tactic alone will be effective. A good pest control operator will develop a strategy to deal with the bed bugs that takes the particulars of the setting into account, and will return several times to check on progress. Dry ice sprays that freeze bed bugs have limited potential to reach hidden bugs. Steam has somewhat better penetrating ability. The downside of steam is that it leaves moisture behind. Dry ice doesn't leave any residue at all. Vacuuming has a role, but it has limitations, too. Some insecticides leave behind deposits that are slow to act but are effective in the long-term. Other insecticides kill on contact, but only reach insects that are in view. Insecticide resistance makes the choice of tactics more difficult.
Hey Ruth! If there are absolutely no signs of bed bugs (upon close inspection), its unlikely that they are the cause for the bite marks. I recommend taking another look for dark brown marks (dried blood) and other signs of their presence. Regardless, if you want to kill any bug on that mattress, just get a handheld steamer and blast it. The heat will kill everything and its completely natural. Hope that helps!

I have been suffering from these stupid bed bugs but i want to know if the baking soda mixture thing only cures the itchiness or make the spots disappear because i try as much as possible not to scratch it because it makes it expand. I am looking for something to make my skin color be maintained not to be having unwanted spots all over. I’m on the heating business to cure the bugs though. Thanks for the hints.
Bedbug bite reactions are self-limited and typically resolve within one to two weeks without intervention.15 There is no evidence that any treatment alters the natural history of bedbug dermatitis.8 If pruritus is present, nonprescription topical antipruritic preparations containing the active ingredient doxepin, or intermediate potency corticosteroids may be beneficial. Mupirocin (Bactroban) and/or systemic antibiotics should be considered in the treatment of superinfected bites.8

We took extreme measures and hired a Heat company to come in. They heat your house to approx 150 degrees (internal wall temp of 140 or more). Bed bugs can survive for 7 minutes at 115 degrees. The heat company heats your house to well above that temp and maintains it for 4 hours! It was great!!!! We have not seen a bed bug since…except for dead ones!! I will warn everyone…the treatment is not cheap. We have a 3200 sq foot house that is only 2 years old…the cost was $4000. They base the cost on square footage, age of home, insulation, etc. I freaked when I heard the estimate, but worth the money to be rid of them!!
Bed bug infestations are primarily the result of two species of insects from genus Cimex: Cimex lectularius (the common bed bug) and Cimex hemipterus.[3] These insects feed exclusively on blood and may survive a year without eating.[3] Adult Cimex are light brown to reddish-brown, flat, oval, and have no hind wings. The front wings are vestigial and reduced to pad-like structures. Adults grow to 4–5 mm (0.16–0.20 in) long and 1.5–3 mm (0.059–0.118 in) wide.
Everything you need to know about bedbugs Bedbugs are small wingless insects that feed exclusively on the blood of warm-blooded animals. They need to feed regularly to reproduce, lay eggs, and survive. Two species eat human blood, usually feeding during the night. In this article, we explain the typical signs of bedbugs in the home and how to remove them. Read now
Unlike those of other insects, bed bug bites may sometimes appear in tight lines of multiple, small, red marks where multiple bed bugs have fed along an exposed area. Bed bug bites can cause itchiness. Initially, a victim may detect a slight burning sensation. The burning area then develops red bumps, known as papules or wheals (rash). In extreme cases, bites may swell dramatically or turn into blister-like skin inflammations.
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