Hey Ruth! If there are absolutely no signs of bed bugs (upon close inspection), its unlikely that they are the cause for the bite marks. I recommend taking another look for dark brown marks (dried blood) and other signs of their presence. Regardless, if you want to kill any bug on that mattress, just get a handheld steamer and blast it. The heat will kill everything and its completely natural. Hope that helps!
Bring a little flashlight—hotel room lighting is always pretty poor and the dimmer the lighting, the harder it is to see small bed bugs or their fecal spots. I would pull back the bed covers and look all around the head of the bed. Pull back the sheets, too, and look at mattress seams and edges that are exposed. bed bugs love to hide under mattress tags. Look all around the box springs, too. If there's a dust ruffle, pull it up and look under it as much as possible. Look for moving bugs and stationary, hiding bugs.
Vigilant travelers may also want to elevate suitcases off the floor on a stand, tabletop or other hard surface rather than storing them on the floor or another bed. Hyper-vigilant travelers may further opt to keep belongings in sealed plastic pouches and their suitcase in a zippered tote — however each traveler must decide how cautious they wish to be. 
Its important to note that bed bugs can easily be transferred from other locations (such as hotels, friends, etc.) into your bedroom, something your definitely want to avoid! Its important to always check your skin, clothing and bags for any signs of bed bugs (and their bites) before entering your bedroom after sleeping away from the home. If you have been bitten a couple times, there is usually no urgent need for medical care. In fact, there are a number of effective home remedies that you can use to treat these insect bites. However, sometimes medical assistance is required. When is this the case and how can you identify when professional help is needed?
All my life i’ve been allergic to basically everything i thought it was a normal allergic reaction…when i went to the doctors she told me it looks like a random bug bite not a bed bug bite but i didn’t believe her she sent me home with some cream and steroids for the swolleness…but why i think most doctors lie to u idk because i google’d the cream she gave me it was for scabies {so that means i got bit by a begbug and didn’t even know} not even a doctor knows half of the times what are things…thank god i read up and treated my self for bedbugs!
Bed bugs do not transmit MRSA. Although there have been reports of persons developing methicillin resistant Staphylococcus aureus (MRSA) infections, such as boils or abscesses associated with bed bug bites, it turns out the bed bugs really weren't directly at fault. Rather, the cases of MRSA infections associated with bed bug bites are actually an example of scratching leading to minor skin trauma and subsequent secondary bacterial infections. In these cases, people who are carriers of MRSA scratch at the itchy bite sites and provide a port of entry for the MRSA (which was already present on their skin) to get in and under the skin and cause the secondary infection. While it can be blamed for some other bed bug symptoms like itching and red welts, the bed bug cannot be blamed for the infection.

We have already replaced are furniture, threw out our bed that we still haven’t be able to afford to replace I have treated the house daily with sparaies and powders. We have torn up our carpet one three rooms of the house. Did all that before getting new furniture but yet we still can’t seem to rid of these bedbugs. The infestation doesn’t seem to be as bad, yet we are still getting bitten nightly by them we don’t have a lot of money we are struggling the way it…help what can I do
While cleaning up infested areas will be helpful in controlling bedbugs, getting rid of them usually requires chemical treatments. Because treating your bed and bedroom with insecticides can be harmful, it is important to use products that can be used safely in bedrooms. Do not treat mattresses and bedding unless the label specifically says you can use them on bedding.
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